Antifungal Combinations against Candida albicans Biofilms In Vitro

Stefano P. Bachmann; Gordon Ramage; Kacy VandeWalle; Thomas F. Patterson; Brian L. Wickes; José L. López-Ribot

doi:10.1128/AAC.47.11.3657-3659.2003

Antifungal Combinations against Candida albicans Biofilms In Vitro

Stefano P. Bachmann
, Gordon Ramage
, Kacy VandeWalle
, Thomas F. Patterson
, Brian L. Wickes
, José L. López-Ribot

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

Original language	English (US)
Pages (from-to)	3657-3659
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	47
Issue number	11
DOIs	https://doi.org/10.1128/AAC.47.11.3657-3659.2003
State	Published - Nov 2003

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/AAC.47.11.3657-3659.2003

Cite this

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abstract = "Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.",

author = "Bachmann, \{Stefano P.\} and Gordon Ramage and Kacy VandeWalle and Patterson, \{Thomas F.\} and Wickes, \{Brian L.\} and L{\'o}pez-Ribot, \{Jos{\'e} L.\}",

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AU - Bachmann, Stefano P.

AU - Ramage, Gordon

AU - VandeWalle, Kacy

AU - Patterson, Thomas F.

AU - Wickes, Brian L.

AU - López-Ribot, José L.

PY - 2003/11

Y1 - 2003/11

N2 - Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

AB - Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

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U2 - 10.1128/AAC.47.11.3657-3659.2003

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IS - 11

ER -

Antifungal Combinations against Candida albicans Biofilms In Vitro

Abstract

ASJC Scopus subject areas

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