Antifungal Combinations against Candida albicans Biofilms In Vitro

Stefano P. Bachmann, Gordon Ramage, Kacy VandeWalle, Thomas F Patterson, Brian L Wickes, José L. López-Ribot

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

Original languageEnglish (US)
Pages (from-to)3657-3659
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number11
DOIs
StatePublished - Nov 2003

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caspofungin
Fluconazole
Antifungal Agents
Biofilms
Candida albicans
Amphotericin B
Candida
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Antifungal Combinations against Candida albicans Biofilms In Vitro. / Bachmann, Stefano P.; Ramage, Gordon; VandeWalle, Kacy; Patterson, Thomas F; Wickes, Brian L; López-Ribot, José L.

In: Antimicrobial Agents and Chemotherapy, Vol. 47, No. 11, 11.2003, p. 3657-3659.

Research output: Contribution to journalArticle

Bachmann, Stefano P. ; Ramage, Gordon ; VandeWalle, Kacy ; Patterson, Thomas F ; Wickes, Brian L ; López-Ribot, José L. / Antifungal Combinations against Candida albicans Biofilms In Vitro. In: Antimicrobial Agents and Chemotherapy. 2003 ; Vol. 47, No. 11. pp. 3657-3659.
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