TY - JOUR
T1 - Antifungal Combinations against Candida albicans Biofilms In Vitro
AU - Bachmann, Stefano P.
AU - Ramage, Gordon
AU - VandeWalle, Kacy
AU - Patterson, Thomas F.
AU - Wickes, Brian L.
AU - López-Ribot, José L.
PY - 2003/11
Y1 - 2003/11
N2 - Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.
AB - Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.
UR - http://www.scopus.com/inward/record.url?scp=0242322572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242322572&partnerID=8YFLogxK
U2 - 10.1128/AAC.47.11.3657-3659.2003
DO - 10.1128/AAC.47.11.3657-3659.2003
M3 - Article
C2 - 14576141
AN - SCOPUS:0242322572
SN - 0066-4804
VL - 47
SP - 3657
EP - 3659
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 11
ER -