Antifungal Combinations against Candida albicans Biofilms In Vitro

Stefano P. Bachmann, Gordon Ramage, Kacy VandeWalle, Thomas F. Patterson, Brian L. Wickes, José L. López-Ribot

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

Original languageEnglish (US)
Pages (from-to)3657-3659
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume47
Issue number11
DOIs
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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