Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials

Xinbo Sun, Zhengbing Cao, Chih-ko Yeh, Yuyu Sun

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Colonization and biofilm-formation of Candida species on denture surfaces cause Candida-associated denture stomatitis (CADS), a common, recurring disease affecting up to 67% of denture wearers. We developed poly(. N-vinyl-2-pyrrolidinone)-grafted denture materials that can be repeatedly recharged with various antifungal drugs to achieve long-term antifungal and biofilm-controlling effects. The monomer, N-vinyl-2-pyrrolidinone (NVP), was grafted onto poly(methyl methacrylate) denture resins through plasma-initiated grafting polymerization. The physical properties and biocompatibility of the resulting resins were not negatively affected by the presence of up to 7.92% of grafted poly (. N-vinyl-2-pyrrolidinone) (PNVP). Miconazole and chlorhexidine digluconate (CD) were used as model antifungal drugs. PNVP grafting significantly increased the drug absorption capability of the resulting denture materials. Further, the new materials showed sustained drug release and provided antifungal effects for weeks (in the case of CD) to months (in the case of miconazole). The drug-depleted resins could be recharged with the same or a different class of antifungal drug to further extend antifungal duration. If needed, drugs on the PNVP-grafted denture materials could be "washed out" (quenched) by treating with PNVP aqueous solutions to stop drug release. These results point to great potentials of the new materials in controlling biofilm-formation in a wide range of device-related applications.

Original languageEnglish (US)
Pages (from-to)96-104
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume110
DOIs
StatePublished - Oct 1 2013

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Dental prostheses
biofilms
Dentures
Biofilms
biocompatibility
Biocompatibility
drugs
Pharmaceutical Preparations
Miconazole
Resins
Candida
Denture Stomatitis
resins
Polymethyl Methacrylate
Polymerization
acrylic resins
N-vinyl-2-pyrrolidinone
Polymethyl methacrylates
polymethyl methacrylate
Physical properties

Keywords

  • Biocompatibility
  • Biofilm
  • Denture
  • Drug delivery
  • Poly(N-vinyl-2-pyrrolidinone)

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials. / Sun, Xinbo; Cao, Zhengbing; Yeh, Chih-ko; Sun, Yuyu.

In: Colloids and Surfaces B: Biointerfaces, Vol. 110, 01.10.2013, p. 96-104.

Research output: Contribution to journalArticle

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abstract = "Colonization and biofilm-formation of Candida species on denture surfaces cause Candida-associated denture stomatitis (CADS), a common, recurring disease affecting up to 67{\%} of denture wearers. We developed poly(. N-vinyl-2-pyrrolidinone)-grafted denture materials that can be repeatedly recharged with various antifungal drugs to achieve long-term antifungal and biofilm-controlling effects. The monomer, N-vinyl-2-pyrrolidinone (NVP), was grafted onto poly(methyl methacrylate) denture resins through plasma-initiated grafting polymerization. The physical properties and biocompatibility of the resulting resins were not negatively affected by the presence of up to 7.92{\%} of grafted poly (. N-vinyl-2-pyrrolidinone) (PNVP). Miconazole and chlorhexidine digluconate (CD) were used as model antifungal drugs. PNVP grafting significantly increased the drug absorption capability of the resulting denture materials. Further, the new materials showed sustained drug release and provided antifungal effects for weeks (in the case of CD) to months (in the case of miconazole). The drug-depleted resins could be recharged with the same or a different class of antifungal drug to further extend antifungal duration. If needed, drugs on the PNVP-grafted denture materials could be {"}washed out{"} (quenched) by treating with PNVP aqueous solutions to stop drug release. These results point to great potentials of the new materials in controlling biofilm-formation in a wide range of device-related applications.",
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