Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression

Helen Lavretsky, Donna Roybal, Martina Ballmaier, Arthur W. Toga, Anand Kumar

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objectives: Depressed elderly patients with and without antidepressant exposure were compared to normal controls to examine the effects of prior antidepressant exposure on regional brain gray matter volumes using magnetic resonance imaging (MRI). Method: The study was conducted from October 1999 to January 2003. Patients and controls were closely matched by age and education. They underwent comprehensive neuropsychiatric and physical examinations. Measures of the total frontal lobe and the frontal gray and white matter volumes corrected by the intracranial volume were obtained using MRI, together with clinical measures of medical burden. Historical information about prior exposure to antidepressant drugs was collected using multiple information sources. The groups were compared using multivariate analyses of covariance, controlling for age, sex, and medical burden. Results: The study sample comprised 41 patients who met the DSM-IV criteria for major depressive disorder (32 women; 11 antidepressant exposure and 30 drug-naive; mean age 70.5 years) and 41 controls (20 women; mean age 72.2 years). In the multivariate analysis, the depressed group had smaller corrected orbitofrontal cortex (OFC) total and gray matter volumes compared to the controls (p < .01). However, depressed patients with prior antidepressant exposure had larger OFC gray matter volumes compared to drug-naive depressed patients, but smaller than those in normal controls (p = .005). This effect was not explained by the group differences in sex ratio, age at onset of depression, or the number or duration of depressive episodes. Conclusions: We observed larger OFC regional volumes in depressed patients exposed to antidepressants compared to the drug-naive depressed subjects, but smaller than those in age-matched controls. Antidepressant exposure may protect against gray matter loss in geriatric depression.

Original languageEnglish (US)
Pages (from-to)964-967
Number of pages4
JournalJournal of Clinical Psychiatry
Volume66
Issue number8
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Geriatrics
Antidepressive Agents
Depression
Prefrontal Cortex
Multivariate Analysis
Magnetic Resonance Imaging
Pharmaceutical Preparations
Sex Ratio
Major Depressive Disorder
Frontal Lobe
Gray Matter
Age of Onset
Diagnostic and Statistical Manual of Mental Disorders
Physical Examination
Education
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression. / Lavretsky, Helen; Roybal, Donna; Ballmaier, Martina; Toga, Arthur W.; Kumar, Anand.

In: Journal of Clinical Psychiatry, Vol. 66, No. 8, 01.01.2005, p. 964-967.

Research output: Contribution to journalArticle

Lavretsky, Helen ; Roybal, Donna ; Ballmaier, Martina ; Toga, Arthur W. ; Kumar, Anand. / Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression. In: Journal of Clinical Psychiatry. 2005 ; Vol. 66, No. 8. pp. 964-967.
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