Anticonvulsants in bipolar disorder

Charles L. Bowden, Nancy U. Karren

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: To review the literature on the effectiveness of anticonvulsant drugs in the management of bipolar disorder. Methods: A selective review of the literature. Results: Valproate is an effective drug, alone or in combination, for mania, but has limited benefit in bipolar depression. Although valproate is widely used in maintenance therapy of bipolar disorder, and secondary analyses suggest benefit, in the largest randomised maintenance trial there was only a trend favouring valproate. Lamotrigine has benefit in bipolar depression and maintenance, but not in mania. Carbamazepine is effective in mania. Other anticonvulsant drugs have been tried in mania, but with mixed results. Conclusions: Valproate, lamotrigine and carbamazepine have a valuable place in the management of bipolar disorder.

Original languageEnglish (US)
Pages (from-to)386-393
Number of pages8
JournalAustralian and New Zealand Journal of Psychiatry
Volume40
Issue number5
DOIs
StatePublished - May 2006

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Bipolar Disorder
Anticonvulsants
Valproic Acid
Carbamazepine
Maintenance
Pharmaceutical Preparations

Keywords

  • Anticonvulsant
  • Bipolar
  • Carbamazepine
  • Lamotrigine
  • Valproate

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Anticonvulsants in bipolar disorder. / Bowden, Charles L.; Karren, Nancy U.

In: Australian and New Zealand Journal of Psychiatry, Vol. 40, No. 5, 05.2006, p. 386-393.

Research output: Contribution to journalArticle

Bowden, Charles L. ; Karren, Nancy U. / Anticonvulsants in bipolar disorder. In: Australian and New Zealand Journal of Psychiatry. 2006 ; Vol. 40, No. 5. pp. 386-393.
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