Anticancer activity of limonoid from Khaya senegalensis

Huaping Zhang, Xi Wang, Feng Chen, Xiao M. Androulakis, Michael J. Wargovich

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.

Original languageEnglish (US)
Pages (from-to)731-734
Number of pages4
JournalPhytotherapy Research
Volume21
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

Keywords

  • 1-O-acetylkhayanolide B
  • 3α,7α-dideacetylkhivorin
  • Antiproliferative activity
  • Khaya senegalensis
  • Limonoid
  • Meliaceae

ASJC Scopus subject areas

  • Pharmacology

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