Anticancer activity of limonoid from Khaya senegalensis

Huaping Zhang; Xi Wang; Feng Chen; Xiao M. Androulakis; Michael J. Wargovich

doi:10.1002/ptr.2148

Anticancer activity of limonoid from Khaya senegalensis

Huaping Zhang, Xi Wang, Feng Chen, Xiao M. Androulakis, Michael J. Wargovich

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of ¹H and ¹³C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, ¹H-¹H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC₅₀ values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.

Original language	English (US)
Pages (from-to)	731-734
Number of pages	4
Journal	Phytotherapy Research
Volume	21
Issue number	8
DOIs	https://doi.org/10.1002/ptr.2148
State	Published - Aug 2007
Externally published	Yes

Keywords

1-O-acetylkhayanolide B
3α,7α-dideacetylkhivorin
Antiproliferative activity
Khaya senegalensis
Limonoid
Meliaceae

ASJC Scopus subject areas

Pharmacology

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10.1002/ptr.2148

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title = "Anticancer activity of limonoid from Khaya senegalensis",

abstract = "Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.",

keywords = "1-O-acetylkhayanolide B, 3α,7α-dideacetylkhivorin, Antiproliferative activity, Khaya senegalensis, Limonoid, Meliaceae",

author = "Huaping Zhang and Xi Wang and Feng Chen and Androulakis, {Xiao M.} and Wargovich, {Michael J.}",

year = "2007",

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language = "English (US)",

volume = "21",

pages = "731--734",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

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AU - Zhang, Huaping

AU - Wang, Xi

AU - Chen, Feng

AU - Androulakis, Xiao M.

AU - Wargovich, Michael J.

PY - 2007/8

Y1 - 2007/8

N2 - Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.

AB - Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.

KW - 1-O-acetylkhayanolide B

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