Anticancer activity of limonoid from Khaya senegalensis

Huaping Zhang; Xi Wang; Feng Chen; Xiao M. Androulakis; Michael J. Wargovich

doi:10.1002/ptr.2148

Anticancer activity of limonoid from Khaya senegalensis

Huaping Zhang, Xi Wang, Feng Chen, Xiao M. Androulakis, Michael J. Wargovich

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of ¹H and ¹³C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, ¹H-¹H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC₅₀ values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.

Original language	English (US)
Pages (from-to)	731-734
Number of pages	4
Journal	Phytotherapy Research
Volume	21
Issue number	8
DOIs	https://doi.org/10.1002/ptr.2148
State	Published - Aug 2007
Externally published	Yes

Keywords

1-O-acetylkhayanolide B
3α,7α-dideacetylkhivorin
Antiproliferative activity
Khaya senegalensis
Limonoid
Meliaceae

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1002/ptr.2148

Cite this

@article{39ffe4b5e1cb402c9241f7b857af334a,

title = "Anticancer activity of limonoid from Khaya senegalensis",

abstract = "Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.",

keywords = "1-O-acetylkhayanolide B, 3α,7α-dideacetylkhivorin, Antiproliferative activity, Khaya senegalensis, Limonoid, Meliaceae",

author = "Huaping Zhang and Xi Wang and Feng Chen and Androulakis, {Xiao M.} and Wargovich, {Michael J.}",

year = "2007",

month = aug,

doi = "10.1002/ptr.2148",

language = "English (US)",

volume = "21",

pages = "731--734",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

number = "8",

}

TY - JOUR

T1 - Anticancer activity of limonoid from Khaya senegalensis

AU - Zhang, Huaping

AU - Wang, Xi

AU - Chen, Feng

AU - Androulakis, Xiao M.

AU - Wargovich, Michael J.

PY - 2007/8

Y1 - 2007/8

N2 - Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.

AB - Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α- dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H-1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC50 values in the range of 0.07-0.14 μM (35-69 ppm) while compound 2 did not.

KW - 1-O-acetylkhayanolide B

KW - 3α,7α-dideacetylkhivorin

KW - Antiproliferative activity

KW - Khaya senegalensis

KW - Limonoid

KW - Meliaceae

UR - http://www.scopus.com/inward/record.url?scp=34547683549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547683549&partnerID=8YFLogxK

U2 - 10.1002/ptr.2148

DO - 10.1002/ptr.2148

M3 - Article

C2 - 17450502

AN - SCOPUS:34547683549

VL - 21

SP - 731

EP - 734

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 8

ER -

Anticancer activity of limonoid from Khaya senegalensis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this