Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients

Yuriy V. Shebzukhov; Ekaterina P. Koroleva; Svetlana V. Khlgatian; Pavel V. Belousov; Ksenia E. Kuz'Mina; Boris V. Radko; Fanny Longpre; Maria A. Lagarkeva; Tatiana S. Kadachigova; Olga V. Gurova; Andrey A. Meshcheryakov; Mikhail R. Lichinitser; Alexander Knuth; Elke Jager; Dmitry V. Kuprash; Sergei A. Nedospasov

doi:10.1002/ijc.21240

Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients

Yuriy V. Shebzukhov
, Ekaterina P. Koroleva
, Svetlana V. Khlgatian
, Pavel V. Belousov
, Ksenia E. Kuz'Mina
, Boris V. Radko
, Fanny Longpre
, Maria A. Lagarkeva
, Tatiana S. Kadachigova
, Olga V. Gurova
, Andrey A. Meshcheryakov
, Mikhail R. Lichinitser
, Alexander Knuth
, Elke Jager
, Dmitry V. Kuprash
, Sergei A. Nedospasov

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Antibodies to cancer antigens can often be detected in the sera of patients, although the mechanism of the underlying humoral immune response is poorly understood. Using immunoscreening of tumor-derived cDNA expression libraries (SEREX), we identified human histone deacetylase 3 (HDAC3) as serologically defined antigen in colon cancer. Closely related HDAC1 and HDAC2 do not elicit humoral response in colon cancer patients. We show that the C-terminal region of HDAC3 protein lacking the homology to other Class I HDAC contains at least 3 distinct B-cell epitopes that are recognized by the serum antibodies. HDAC3 in combination with other SEREX antigens may become a useful molecular biomarker with diagnostic or prognostic value for a subset of colon cancer patients. (Supplementary material for this article can be found on the International Journal of Cancer website at http://www. interscience.wiley.com/ jpages/0020-7136/suppmat/index.html).

Original language	English (US)
Pages (from-to)	800-806
Number of pages	7
Journal	International Journal of Cancer
Volume	117
Issue number	5
DOIs	https://doi.org/10.1002/ijc.21240
State	Published - Dec 10 2005
Externally published	Yes

Keywords

Antibodies
Epitopes
HDAC3
Serology

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/ijc.21240

Cite this

Shebzukhov, Y. V., Koroleva, E. P., Khlgatian, S. V., Belousov, P. V., Kuz'Mina, K. E., Radko, B. V., Longpre, F., Lagarkeva, M. A., Kadachigova, T. S., Gurova, O. V., Meshcheryakov, A. A., Lichinitser, M. R., Knuth, A., Jager, E., Kuprash, D. V., & Nedospasov, S. A. (2005). Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients. International Journal of Cancer, 117(5), 800-806. https://doi.org/10.1002/ijc.21240

Shebzukhov, YV, Koroleva, EP, Khlgatian, SV, Belousov, PV, Kuz'Mina, KE, Radko, BV, Longpre, F, Lagarkeva, MA, Kadachigova, TS, Gurova, OV, Meshcheryakov, AA, Lichinitser, MR, Knuth, A, Jager, E, Kuprash, DV & Nedospasov, SA 2005, 'Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients', International Journal of Cancer, vol. 117, no. 5, pp. 800-806. https://doi.org/10.1002/ijc.21240

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abstract = "Antibodies to cancer antigens can often be detected in the sera of patients, although the mechanism of the underlying humoral immune response is poorly understood. Using immunoscreening of tumor-derived cDNA expression libraries (SEREX), we identified human histone deacetylase 3 (HDAC3) as serologically defined antigen in colon cancer. Closely related HDAC1 and HDAC2 do not elicit humoral response in colon cancer patients. We show that the C-terminal region of HDAC3 protein lacking the homology to other Class I HDAC contains at least 3 distinct B-cell epitopes that are recognized by the serum antibodies. HDAC3 in combination with other SEREX antigens may become a useful molecular biomarker with diagnostic or prognostic value for a subset of colon cancer patients. (Supplementary material for this article can be found on the International Journal of Cancer website at http://www. interscience.wiley.com/ jpages/0020-7136/suppmat/index.html).",

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AU - Gurova, Olga V.

AU - Meshcheryakov, Andrey A.

AU - Lichinitser, Mikhail R.

AU - Knuth, Alexander

AU - Jager, Elke

AU - Kuprash, Dmitry V.

AU - Nedospasov, Sergei A.

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AB - Antibodies to cancer antigens can often be detected in the sera of patients, although the mechanism of the underlying humoral immune response is poorly understood. Using immunoscreening of tumor-derived cDNA expression libraries (SEREX), we identified human histone deacetylase 3 (HDAC3) as serologically defined antigen in colon cancer. Closely related HDAC1 and HDAC2 do not elicit humoral response in colon cancer patients. We show that the C-terminal region of HDAC3 protein lacking the homology to other Class I HDAC contains at least 3 distinct B-cell epitopes that are recognized by the serum antibodies. HDAC3 in combination with other SEREX antigens may become a useful molecular biomarker with diagnostic or prognostic value for a subset of colon cancer patients. (Supplementary material for this article can be found on the International Journal of Cancer website at http://www. interscience.wiley.com/ jpages/0020-7136/suppmat/index.html).

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Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients

Abstract

Keywords

ASJC Scopus subject areas

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