Antibody independent activation of human C1 after interaction with heart subcellular membranes

R. N. Pinckard, M. S. Olson, R. E. Kelley, D. H. DeHeer, J. D. Palmer, R. A. O'Rourke, S. Goldfein

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

A 19S, complement fixing, heat labile factor reactive with human heart mitochondria and microsomes has been detected in all normal human serum. This serum factor reacted with autologous and homologous heart mitochondria but did not react with mitochondria derived from cardiac tissue from other species. Subsequent characterization has indicated that this heat labile factor was the first component of human complement. The C1 reacted with the mitochondrial membrane, was activated, and resulted in an apparent antibody independent activation of the complement system.

Original languageEnglish (US)
Pages (from-to)1376-1382
Number of pages7
JournalJournal of Immunology
Volume110
Issue number5
StatePublished - Dec 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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