Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis)

D. M. Williams, J. Schachter, M. H. Weiner, B. Grubbs

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In a murine model of chlamydial pneumonia employing murine Chlamydia trachomatis, immune serum given intranasally delayed death in nude (nu/nu) mice and prevented death in nu/+ mice. Serum-derived immunoglobulin G and A fractions and immune lavage fluid fractions containing immunoglobulins G and A were effective in producing protection when used to opsonize the murine C. trachomatis inoculum. In hyperclean mice (previously made germfree and then colonized with a limited flora nonpathogenic to mice) antibody given intravenously was ineffective. The effects of antibody and nonspecific stimulation of cell-mediated immunity (after previous infection with Histoplasma capsulatum) were additive in increasing host resistance to murine C. trachomatis.

Original languageEnglish (US)
Pages (from-to)674-678
Number of pages5
JournalInfection and Immunity
Volume45
Issue number3
StatePublished - Jan 1 1984

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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