Antibodies to polyadenylic acid in patients with myasthenia gravis

M. Fischbach, J. Lindstrom, N. Talal

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Sera from 100 patients with myasthenia gravis and 45 patients with non-myasthenia gravis neuromuscular diseases were studied for antibodies to poly rA, poly rA.rU, native and denatured DNA. All patients with myasthenia gravis had significant anti-acetylcholine receptor antibodies with a mean titre of 1.2 x 10-7 M. Forty-eight per cent of the myasthenia gravis patients had anti-poly rA antibody levels which were greater than 3 standard deviations from the mean of 65 control patients by Millipore filter radioimmunoassay. The antibody was specific for poly rA and present in a much higher frequency than antibodies to the other nucleic acids tested. Sucrose-gradient ultracentrifugation demonstrated that the antibody was limited to the IgM class alone. Mechanisms relating these findings to a more generalized immunological dysfunction are discussed.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalClinical and Experimental Immunology
Volume43
Issue number1
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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