Antibodies to Chlamydia trachomatis and risk for tubal pregnancy

Mark D. Walters, Carlton A. Eddy, Ronald S. Gibbs, Julius Schachter, Alan E.C. Holden, Carl J. Pauerstein

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


We performed a case-control study of the effect of exposure to Chlamydia trachomatis on the risk for tubal pregnancy. Sixty women with tubal pregnancies and 60 matched control women with normal second-trimester intrauterine pregnancies were studied. Cases were more likely than controls to have detectable antichlamydial IgG antibodies (82% versus 58%, p < 0.01) and their mean titers were higher. The prevalence of IgM antibody seropositivity was not different between cases and controls (20% versus 12%, not significant). Compared with women with IgG antibody titers of ⩽1:8 the relative risk for tubal pregnancy for women with titers ⩾1:128 was 6.6 (95% confidence interval, 2.0 to 21.6). Among women with tubal pregnancies, antichlamydial antibody titers of ⩾1:128 were significantly associated with pelvic adhesions and inflammatory tubal mucosal damage. Only 17.6% of women with detectable antichlamydial antibody or inflammatory tubal damage reported a history of pelvic inflammatory disease or gonorrhea.

Original languageEnglish (US)
Pages (from-to)942-946
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
StatePublished - 1988
Externally publishedYes


  • Chlamydia trachomatis
  • Ectopic pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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