Abstract
We performed a case-control study of the effect of exposure to Chlamydia trachomatis on the risk for tubal pregnancy. Sixty women with tubal pregnancies and 60 matched control women with normal second-trimester intrauterine pregnancies were studied. Cases were more likely than controls to have detectable antichlamydial IgG antibodies (82% versus 58%, p < 0.01) and their mean titers were higher. The prevalence of IgM antibody seropositivity was not different between cases and controls (20% versus 12%, not significant). Compared with women with IgG antibody titers of ≤1:8 the relative risk for tubal pregnancy for women with titers ≥1:128 was 6.6 (95% confidence interval, 2.0 to 21.6). Among women with tubal pregnancies, antichlamydial antibody titers of ≥1:128 were significantly associated with pelvic adhesions and inflammatory tubal mucosal damage. Only 17.6% of women with detectable antichlamydial antibody or inflammatory tubal damage reported a history of pelvic inflammatory disease or gonorrhea.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 942-946 |
| Number of pages | 5 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 159 |
| Issue number | 4 |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Antibodies to Chlamydia trachomatis and risk for tubal pregnancy. / Walters, M. D.; Eddy, C. A.; Gibbs, R. S.; Schachter, J.; Holden, A. E C; Pauerstein, C. J.
In: American Journal of Obstetrics and Gynecology, Vol. 159, No. 4, 1988, p. 942-946.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibodies to Chlamydia trachomatis and risk for tubal pregnancy
AU - Walters, M. D.
AU - Eddy, C. A.
AU - Gibbs, R. S.
AU - Schachter, J.
AU - Holden, A. E C
AU - Pauerstein, C. J.
PY - 1988
Y1 - 1988
N2 - We performed a case-control study of the effect of exposure to Chlamydia trachomatis on the risk for tubal pregnancy. Sixty women with tubal pregnancies and 60 matched control women with normal second-trimester intrauterine pregnancies were studied. Cases were more likely than controls to have detectable antichlamydial IgG antibodies (82% versus 58%, p < 0.01) and their mean titers were higher. The prevalence of IgM antibody seropositivity was not different between cases and controls (20% versus 12%, not significant). Compared with women with IgG antibody titers of ≤1:8 the relative risk for tubal pregnancy for women with titers ≥1:128 was 6.6 (95% confidence interval, 2.0 to 21.6). Among women with tubal pregnancies, antichlamydial antibody titers of ≥1:128 were significantly associated with pelvic adhesions and inflammatory tubal mucosal damage. Only 17.6% of women with detectable antichlamydial antibody or inflammatory tubal damage reported a history of pelvic inflammatory disease or gonorrhea.
AB - We performed a case-control study of the effect of exposure to Chlamydia trachomatis on the risk for tubal pregnancy. Sixty women with tubal pregnancies and 60 matched control women with normal second-trimester intrauterine pregnancies were studied. Cases were more likely than controls to have detectable antichlamydial IgG antibodies (82% versus 58%, p < 0.01) and their mean titers were higher. The prevalence of IgM antibody seropositivity was not different between cases and controls (20% versus 12%, not significant). Compared with women with IgG antibody titers of ≤1:8 the relative risk for tubal pregnancy for women with titers ≥1:128 was 6.6 (95% confidence interval, 2.0 to 21.6). Among women with tubal pregnancies, antichlamydial antibody titers of ≥1:128 were significantly associated with pelvic adhesions and inflammatory tubal mucosal damage. Only 17.6% of women with detectable antichlamydial antibody or inflammatory tubal damage reported a history of pelvic inflammatory disease or gonorrhea.
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M3 - Article
C2 - 3177550
AN - SCOPUS:0023796865
VL - 159
SP - 942
EP - 946
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 4
ER -