Antibodies to Chlamydia trachomatis and risk for tubal pregnancy

M. D. Walters, C. A. Eddy, R. S. Gibbs, J. Schachter, A. E C Holden, C. J. Pauerstein

Research output: Contribution to journalArticle

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Abstract

We performed a case-control study of the effect of exposure to Chlamydia trachomatis on the risk for tubal pregnancy. Sixty women with tubal pregnancies and 60 matched control women with normal second-trimester intrauterine pregnancies were studied. Cases were more likely than controls to have detectable antichlamydial IgG antibodies (82% versus 58%, p < 0.01) and their mean titers were higher. The prevalence of IgM antibody seropositivity was not different between cases and controls (20% versus 12%, not significant). Compared with women with IgG antibody titers of ≤1:8 the relative risk for tubal pregnancy for women with titers ≥1:128 was 6.6 (95% confidence interval, 2.0 to 21.6). Among women with tubal pregnancies, antichlamydial antibody titers of ≥1:128 were significantly associated with pelvic adhesions and inflammatory tubal mucosal damage. Only 17.6% of women with detectable antichlamydial antibody or inflammatory tubal damage reported a history of pelvic inflammatory disease or gonorrhea.

Original languageEnglish (US)
Pages (from-to)942-946
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume159
Issue number4
StatePublished - 1988

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Tubal Pregnancy
Chlamydia trachomatis
Antibodies
Immunoglobulin G
Pelvic Inflammatory Disease
Gonorrhea
Second Pregnancy Trimester
Immunoglobulin M
Case-Control Studies
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Walters, M. D., Eddy, C. A., Gibbs, R. S., Schachter, J., Holden, A. E. C., & Pauerstein, C. J. (1988). Antibodies to Chlamydia trachomatis and risk for tubal pregnancy. American Journal of Obstetrics and Gynecology, 159(4), 942-946.

Antibodies to Chlamydia trachomatis and risk for tubal pregnancy. / Walters, M. D.; Eddy, C. A.; Gibbs, R. S.; Schachter, J.; Holden, A. E C; Pauerstein, C. J.

In: American Journal of Obstetrics and Gynecology, Vol. 159, No. 4, 1988, p. 942-946.

Research output: Contribution to journalArticle

Walters, MD, Eddy, CA, Gibbs, RS, Schachter, J, Holden, AEC & Pauerstein, CJ 1988, 'Antibodies to Chlamydia trachomatis and risk for tubal pregnancy', American Journal of Obstetrics and Gynecology, vol. 159, no. 4, pp. 942-946.
Walters MD, Eddy CA, Gibbs RS, Schachter J, Holden AEC, Pauerstein CJ. Antibodies to Chlamydia trachomatis and risk for tubal pregnancy. American Journal of Obstetrics and Gynecology. 1988;159(4):942-946.
Walters, M. D. ; Eddy, C. A. ; Gibbs, R. S. ; Schachter, J. ; Holden, A. E C ; Pauerstein, C. J. / Antibodies to Chlamydia trachomatis and risk for tubal pregnancy. In: American Journal of Obstetrics and Gynecology. 1988 ; Vol. 159, No. 4. pp. 942-946.
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