Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain

Jacob G. Smith; Tomoki Sato; Kohei Shimaji; Kevin B. Koronowski; Paul Petrus; Marlene Cervantes; Kenichiro Kinouchi; Dominik Lutter; Kenneth A. Dyar; Paolo Sassone-Corsi

doi:10.1016/j.lfs.2022.120601

Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain

Jacob G. Smith
, Tomoki Sato
, Kohei Shimaji
, Kevin B. Koronowski
, Paul Petrus
, Marlene Cervantes
, Kenichiro Kinouchi
, Dominik Lutter
, Kenneth A. Dyar
, Paolo Sassone-Corsi

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.

Original language	English (US)
Article number	120601
Journal	Life Sciences
Volume	303
DOIs	https://doi.org/10.1016/j.lfs.2022.120601
State	Published - Aug 15 2022
Externally published	Yes

Keywords

Circadian
Gut-Brain Axis
Metabolism
Microbiome
Neurometabolism
Systems biology

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/j.lfs.2022.120601

Cite this

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title = "Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain",

abstract = "The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.",

keywords = "Circadian, Gut-Brain Axis, Metabolism, Microbiome, Neurometabolism, Systems biology",

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doi = "10.1016/j.lfs.2022.120601",

language = "English (US)",

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journal = "Life Sciences",

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T1 - Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain

AU - Smith, Jacob G.

AU - Sato, Tomoki

AU - Shimaji, Kohei

AU - Koronowski, Kevin B.

AU - Petrus, Paul

AU - Cervantes, Marlene

AU - Kinouchi, Kenichiro

AU - Lutter, Dominik

AU - Dyar, Kenneth A.

AU - Sassone-Corsi, Paolo

PY - 2022/8/15

Y1 - 2022/8/15

N2 - The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.

AB - The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.

KW - Circadian

KW - Gut-Brain Axis

KW - Metabolism

KW - Microbiome

KW - Neurometabolism

KW - Systems biology

UR - https://www.scopus.com/pages/publications/85131381241

UR - https://www.scopus.com/pages/publications/85131381241#tab=citedBy

U2 - 10.1016/j.lfs.2022.120601

DO - 10.1016/j.lfs.2022.120601

M3 - Article

C2 - 35561749

AN - SCOPUS:85131381241

SN - 0024-3205

VL - 303

JO - Life Sciences

JF - Life Sciences

M1 - 120601

ER -

Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain

Abstract

Keywords

ASJC Scopus subject areas

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