Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain

Jacob G. Smith, Tomoki Sato, Kohei Shimaji, Kevin B. Koronowski, Paul Petrus, Marlene Cervantes, Kenichiro Kinouchi, Dominik Lutter, Kenneth A. Dyar, Paolo Sassone-Corsi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.

Original languageEnglish (US)
Article number120601
JournalLife Sciences
Volume303
DOIs
StatePublished - Aug 15 2022
Externally publishedYes

Keywords

  • Circadian
  • Gut-Brain Axis
  • Metabolism
  • Microbiome
  • Neurometabolism
  • Systems biology

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology

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