@inproceedings{8b3bc795b5e04293bcd769ae58f77742,
title = "Anti-VEGFR2 nanogels as a delivery system of therapeutic agents to the brain tumor cells",
abstract = "Conventional approaches in case of primary malignant brain tumors are still low effective in inhibition of tumor progression. Targeted drug delivery using nanocarriers conjugated with monoclonal antibody is an attractive anti-tumor strategy that may significantly improve efficacy of conventional chemotherapeutics delivery to the tumor. Our purpose was to investigate the ability of synthesized nanogels directed against vascular endothelial growth factor receptor II (VEGFR2), a surface receptor widely expressed on activated endothelial cells as well as at sites of tumor angiogenesis. Anti-VEGFR2 nanogels have shown specific binding not only to the rat glioma C6 cells but also to human U-87 MG cells versus unspecific nanogels and nanogels conjugated with IgG. The fluorescence confocal microscopy has revealed that unspecific nanogels and IgG-nanogels have low fluorescent intensity and their localizations within cells are strongly different. These results suggest that targeted anti-VEGFR2 nanogels should be a promising system for selective delivery of chemotherapeutic agents to the VEGFR2 expressing brain tumors.",
keywords = "Anti-VEGFR2 antibody, Anti-VEGFR2 nanogels, Brain tumor, Glioma, Targeted delivery",
author = "Korchagina, {A. A.} and Nukolova, {N. V.} and Shein, {S. A.} and Abakumova, {T. O.} and Chekhonin, {V. P.}",
year = "2014",
language = "English (US)",
series = "NANOCON 2014 - Conference Proceedings, 6th International Conference",
publisher = "TANGER Ltd.",
pages = "575--580",
booktitle = "NANOCON 2014 - Conference Proceedings, 6th International Conference",
note = "6th International Conference on Nanomaterials, NANOCON 2014 ; Conference date: 05-11-2014 Through 07-11-2014",
}