Anti-transforming growth factor beta as a treatment for laryngotracheal stenosis in a canine model

C. Blake Simpson, Stephen White, H. Stan McGuff

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

OBJECTIVES/HYPOTHESIS: Laryngotracheal stenosis (LTS) represents a significant treatment dilemma faced by otolaryngologists. Recent topical use of Mitomycin C as an adjunctive treatment has proved helpful but does not completely prevent stenosis. Current literature suggests that transforming growth factor beta (TGFB) plays a significant role in the development of subglottic stenosis. We modified an existing canine model to test antitransforming growth factor beta (anti-TGFB) as a possible treatment for laryngotracheal stenosis. STUDY DESIGN: Pilot study in a modified canine model. METHODS: Eight mixed-breed dogs underwent cautery injury to the subglottic region creating subsequent laryngotracheal stenosis. Four dogs were treated with saline injection into the injury site and four dogs were treated with a combination of intravenous (5 mg/kg on day 0 and 5 of the experiment) and local injection of anti-TGFB (50 micrograms). RESULTS: In the canine model of induced subglottic airway injury, a combination of intralesional and intravenous anti-TGFB results in a reduction in tracheal stenosis (P < .05) and an increase in survival time (P < .03) when compared to the saline control subjects. CONCLUSIONS: Anti-TGFB appears to be a useful adjunct in the treatment of LTS. Further study regarding the optimal dosing, route of administration, and timing of delivery is needed to understand the role of anti-TGFB in the treatment for laryngotracheal stenosis.

Original languageEnglish (US)
Pages (from-to)546-551
Number of pages6
JournalLaryngoscope
Volume118
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Fibrogenic peptide
  • Growth factors
  • Subglottic stenosis
  • Tracheal stenosis
  • Transforming growth factor beta

ASJC Scopus subject areas

  • Otorhinolaryngology

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