Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees

Ronald C. Kennedy, Jorg W. Eichberg, Robert E. Lanford, Gordon R. Dreesman

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97 Scopus citations

Abstract

Anti-idiotypic antibodies (anti-Id) that contain an internal image component that mimics the surface antigen of hepatitis B virus (HBsAg) were used to immunize chimpanzees. Four injections of the rabbit anti-Id preparation elicited an antibody response to HBsAg (anti-HBs). The antibody specificity appeared to be against the anti-Id, since the anti-Id immunogen was shown to bind the chimpanzee anti-HBs. Two chimpanzees immunized with the anti-Id, along with two control animals that were either untreated or received a nonimmune rabbit immunoglobulin G preparation, were challenged with infectious hepatitis B virus. Both control chimpanzees developed clinical and serological characteristics consistent with an active hepatitis B virus infection, whereas the two anti-Id treated chimpanzees were protected from infection. Since chimpanzees provide a relevant model of a human response to hepatitis B virus immunization and infection, these results indicate that anti-Id preparations such as that described here might be candidates for vaccines against human diseases.

Original languageEnglish (US)
Pages (from-to)220-223
Number of pages4
JournalScience
Volume232
Issue number4747
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • General

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