Anti-ageing peptides and proteins for topical applications: a review

Mengyang Liu, Shuo Chen, Zhiwen Zhang, Hongyu Li, Guiju Sun, Naibo Yin, Jingyuan Wen

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Skin ageing is a cumulative result of oxidative stress, predominantly caused by reactive oxygen species (ROS). Respiration, pollutants, toxins, or ultraviolet A (UVA) irradiation produce ROS with 80% of skin damage attributed to UVA irradiation. Anti-ageing peptides and proteins are considered valuable compounds for removing ROS to prevent skin ageing and maintenance of skin health. In this review, skin ageing theory has been illustrated with a focus on the mechanism and relationship with anti-ageing peptides and proteins. The effects, classification, and transport pathways of anti-ageing peptides and proteins across skin are summarized and discussed. Over the last decade, several novel formulations and advanced strategies have been developed to overcome the challenges in the dermal delivery of proteins and peptides for skin ageing. This article also provides an in-depth review of the latest advancements in the dermal delivery of anti-ageing proteins and peptides. Based on these studies, this review prospected several semi-solid dosage forms to achieve topical applicability for anti-ageing peptides and proteins.

Original languageEnglish (US)
Pages (from-to)108-125
Number of pages18
JournalPharmaceutical Development and Technology
Issue number1
StatePublished - 2022
Externally publishedYes


  • Anti-ageing
  • antioxidants
  • dermal delivery
  • nanoparticulate drug delivery systems
  • proteins and peptides
  • semi-solid dosage forms

ASJC Scopus subject areas

  • Pharmaceutical Science


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