Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages

Shiraz Mujtaba; Benjamin Y. Winer; Anbalagan Jaganathan; Jigneshkumar Patel; Miriam Sgobba; Raymond Schuch; Yogesh K. Gupta; Shozeb Haider; Rong Wang; Vincent A. Fischetti

doi:10.1074/jbc.M113.467696

Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages

Shiraz Mujtaba
, Benjamin Y. Winer
, Anbalagan Jaganathan
, Jigneshkumar Patel
, Miriam Sgobba
, Raymond Schuch
, Yogesh K. Gupta
, Shozeb Haider
, Rong Wang
, Vincent A. Fischetti

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.

Original language	English (US)
Pages (from-to)	23458-23472
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.467696
State	Published - Aug 9 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages",

abstract = "Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.",

author = "Shiraz Mujtaba and Winer, \{Benjamin Y.\} and Anbalagan Jaganathan and Jigneshkumar Patel and Miriam Sgobba and Raymond Schuch and Gupta, \{Yogesh K.\} and Shozeb Haider and Rong Wang and Fischetti, \{Vincent A.\}",

year = "2013",

month = aug,

day = "9",

doi = "10.1074/jbc.M113.467696",

language = "English (US)",

volume = "288",

pages = "23458--23472",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

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TY - JOUR

T1 - Anthrax SET protein

T2 - A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages

AU - Mujtaba, Shiraz

AU - Winer, Benjamin Y.

AU - Jaganathan, Anbalagan

AU - Patel, Jigneshkumar

AU - Sgobba, Miriam

AU - Schuch, Raymond

AU - Gupta, Yogesh K.

AU - Haider, Shozeb

AU - Wang, Rong

AU - Fischetti, Vincent A.

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.

AB - Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.

UR - https://www.scopus.com/pages/publications/84881449055

UR - https://www.scopus.com/pages/publications/84881449055#tab=citedBy

U2 - 10.1074/jbc.M113.467696

DO - 10.1074/jbc.M113.467696

M3 - Article

C2 - 23720780

AN - SCOPUS:84881449055

SN - 0021-9258

VL - 288

SP - 23458

EP - 23472

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 32

ER -

Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages

Abstract

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