Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages

Shiraz Mujtaba, Benjamin Y. Winer, Anbalagan Jaganathan, Jigneshkumar Patel, Miriam Sgobba, Raymond Schuch, Yogesh K. Gupta, Shozeb Haider, Rong Wang, Vincent A. Fischetti

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.

Original languageEnglish (US)
Pages (from-to)23458-23472
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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