Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages

Shiraz Mujtaba, Benjamin Y. Winer, Anbalagan Jaganathan, Jigneshkumar Patel, Miriam Sgobba, Raymond Schuch, Yogesh K. Gupta, Shozeb Haider, Rong Wang, Vincent A. Fischetti

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.

Original languageEnglish (US)
Pages (from-to)23458-23472
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Mujtaba, S., Winer, B. Y., Jaganathan, A., Patel, J., Sgobba, M., Schuch, R., Gupta, Y. K., Haider, S., Wang, R., & Fischetti, V. A. (2013). Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages. Journal of Biological Chemistry, 288(32), 23458-23472. https://doi.org/10.1074/jbc.M113.467696