Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages

Shiraz Mujtaba, Benjamin Y. Winer, Anbalagan Jaganathan, Jigneshkumar Patel, Miriam Sgobba, Raymond Schuch, Yogesh K Gupta, Shozeb Haider, Rong Wang, Vincent A. Fischetti

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The role of SET protein (BaSET) in B. anthracis life cycle was unknown until now. Results: BaSET regulates NF-κB activation, septation, and infectivity. Conclusion: BaSET is one of the key effectors for B. anthracis pathogenesis. Significance: Previous studies predict that SET protein may not have any role in lower organisms. Hence, this is the first report demonstrating SET protein function in a human pathogen.

Original languageEnglish (US)
Pages (from-to)23458-23472
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013
Externally publishedYes

Fingerprint

Anthrax
Macrophages
Staphylococcal Protein A
Virulence
Chemical activation
Proteins
Pathogens
Life Cycle Stages
Life cycle

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Mujtaba, S., Winer, B. Y., Jaganathan, A., Patel, J., Sgobba, M., Schuch, R., ... Fischetti, V. A. (2013). Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages. Journal of Biological Chemistry, 288(32), 23458-23472. https://doi.org/10.1074/jbc.M113.467696

Anthrax SET protein : A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages. / Mujtaba, Shiraz; Winer, Benjamin Y.; Jaganathan, Anbalagan; Patel, Jigneshkumar; Sgobba, Miriam; Schuch, Raymond; Gupta, Yogesh K; Haider, Shozeb; Wang, Rong; Fischetti, Vincent A.

In: Journal of Biological Chemistry, Vol. 288, No. 32, 09.08.2013, p. 23458-23472.

Research output: Contribution to journalArticle

Mujtaba, S, Winer, BY, Jaganathan, A, Patel, J, Sgobba, M, Schuch, R, Gupta, YK, Haider, S, Wang, R & Fischetti, VA 2013, 'Anthrax SET protein: A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages', Journal of Biological Chemistry, vol. 288, no. 32, pp. 23458-23472. https://doi.org/10.1074/jbc.M113.467696
Mujtaba, Shiraz ; Winer, Benjamin Y. ; Jaganathan, Anbalagan ; Patel, Jigneshkumar ; Sgobba, Miriam ; Schuch, Raymond ; Gupta, Yogesh K ; Haider, Shozeb ; Wang, Rong ; Fischetti, Vincent A. / Anthrax SET protein : A potential virulence determinant that epigenetically represses Nf-κB activation in infected macrophages. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 32. pp. 23458-23472.
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