TY - JOUR
T1 - Anterograde memory loss induced by hypothermia in rats
AU - Richardson, Rick
AU - Riccio, David C.
AU - Morilak, David
N1 - Funding Information:
This research was supported in part by NIMH Grant MH30223/MH37535 to D.C.R. David Morilak's contributions were supported under terms of an NSF Undergraduate Research Participation Grant NSF SPI 8025709 to Kent State University. Reprint requests may be addressed to David C. Riccio, Psychology Department, Kent State University, Kent, Ohio 44242.
PY - 1983/1
Y1 - 1983/1
N2 - In contrast with the extensive animal research on retrograde amnesia, relatively little attention has been given to anterograde amnesia. Moreover, previous studies of anterograde amnesia have not always clearly separated the effects of the anterograde treatment on acquisition from those on retention. Thus, hypothermia-induced anterograde amnesia for a one-trial conditioned fear memory was examined in three experiments. Experiment 1A demonstrated an anterograde disruption of performance in subjects receiving training in the hypothermic state (29°C) and tested 24 hr later. Acquisition of the target memory in animals exposed to hypothermia prior to conditioning was demonstrated in Experiment 1B. Subjects conditioned while in a hypothermic state (29°C) performed similarly to noncooled subjects if tested shortly after conditioning (while still in a hypothermic state), but not 24 hr after conditioning (while in a normothermic state). Experiment 2 shows that the anterograde amnesia effect is temperature dependent. That is, of animals trained at 29 or 33°C, only the more hypothermic group demonstrated deficits in retention when tested 24 hr later. This experiment also attempted, unsuccessfully, to demonstrate recovery of the amnestic memory by administration of a noncontingent footshock prior to testing. Implications of the failure to demonstrate recovery of memory are discussed along with possible mechanisms involved in producing anterograde amnesia.
AB - In contrast with the extensive animal research on retrograde amnesia, relatively little attention has been given to anterograde amnesia. Moreover, previous studies of anterograde amnesia have not always clearly separated the effects of the anterograde treatment on acquisition from those on retention. Thus, hypothermia-induced anterograde amnesia for a one-trial conditioned fear memory was examined in three experiments. Experiment 1A demonstrated an anterograde disruption of performance in subjects receiving training in the hypothermic state (29°C) and tested 24 hr later. Acquisition of the target memory in animals exposed to hypothermia prior to conditioning was demonstrated in Experiment 1B. Subjects conditioned while in a hypothermic state (29°C) performed similarly to noncooled subjects if tested shortly after conditioning (while still in a hypothermic state), but not 24 hr after conditioning (while in a normothermic state). Experiment 2 shows that the anterograde amnesia effect is temperature dependent. That is, of animals trained at 29 or 33°C, only the more hypothermic group demonstrated deficits in retention when tested 24 hr later. This experiment also attempted, unsuccessfully, to demonstrate recovery of the amnestic memory by administration of a noncontingent footshock prior to testing. Implications of the failure to demonstrate recovery of memory are discussed along with possible mechanisms involved in producing anterograde amnesia.
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U2 - 10.1016/S0163-1047(83)91089-0
DO - 10.1016/S0163-1047(83)91089-0
M3 - Article
C2 - 6882343
AN - SCOPUS:0020963668
SN - 0163-1047
VL - 37
SP - 76
EP - 88
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 1
ER -