Antacid control of complications from acute gastroduodenal disease after burns

Joseph C. McAlhany, Albert J. Czaja, Basil A. Pruitt

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

To determine the effectiveness of hydrogen ion neutralization in preventing the clinical complications (hemorrhage and perforation) of acute gastroduodenal disease after thermal injury, 48 patients with burns of greater than 35% total body surface were evaluated within 72 hours after injury. In a prospective, randomized fashion, patients were chosen to receive antacid or no-antacid therapy. An established lithium-flux technique was utilized to determine the integrity of the gastric mucosal barrier (GMB) before group selection. Only one of the 24 patients receiving antacid developed significant upper gastrointestinal bleeding; however, seven of 24 patients receiving no antacid experienced hemorrhage and gastric ulcer perforation (p <0.02). None of seven patients with GMB disruption who received antacid developed a clinical complication; however, six of 15 patients with GMB disruption receiving no antacid experienced clinical complications (p <0.05). Neutralization of gastric acid offers protection against the development of clinically significant ulcer complications in the burn patient.

Original languageEnglish (US)
Pages (from-to)645-649
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume16
Issue number8
DOIs
StatePublished - Aug 1976

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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