Animal size, metabolic rate, and survival, among and within species

Steven N. Austad

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Abstract

The positive interspecific relation between mammalian body size and longevity was described more than a century ago and remains one of the most robust patterns known in the biology of aging. Hypotheses about the role of metabolic rate or relative brain size in explaining this pattern have not been supported by detailed analyses. This pattern may be due to an inverse relation between mitochondrial oxygen radical production and body size, although evidence for this hypothesis is sparse. On a less mechanistic level, evolutionary senescence theory provides a compelling rationale that species regardless of size that are less prone to environmental hazards evolve longevity assurance mechanisms leading to longer life-and health span. Considerable evidence suggests that the opposite pattern -smaller size associated with longer life -obtains within species, although detailed information is available for only a few species. Within the species -mice, dogs, and horses -in which this relationship is well-established, the deleterious effects of growth hormone acting either autonomously or through its effect on IGF-I signaling provide a possible explanatory mechanism. Evidence from humans does not appear to conform to this pattern, perhaps because of the dominance of cardiovascular disease as a human cause-of-death.

Original languageEnglish (US)
Title of host publicationThe Comparative Biology of Aging
PublisherSpringer Netherlands
Pages27-41
Number of pages15
ISBN (Print)9789048134649
DOIs
StatePublished - Dec 1 2010

Keywords

  • Body size
  • Comparative biology
  • Energetics
  • Growth hormone
  • IGF-I
  • Mammal longevity
  • Metabolic rate
  • Oxygen radicals
  • Rate of living

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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