Animal models of Pneumococcal pneumonia

Noemi Borsa, Marta Di Pasquale, Marcos I. Restrepo

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Streptococcus pneumoniae remains the most common bacterial pathogen causing lower respiratory tract infections and is a leading cause of morbidity and mortality worldwide, especially in children and the elderly. Another important aspect related to pneumococcal infections is the persistent rate of penicillin and macrolide resistance. Therefore, animal models have been developed to better understand the pathogenesis of pneumococcal disease and test new therapeutic agents and vaccines. This narrative review will focus on the characteristics of the different animal pneumococcal pneumonia models. The assessment of the different animal models will include considerations regarding pneumococcal strains, microbiology properties, procedures used for bacterial inoculation, pathogenesis, clinical characteristics, diagnosis, treatment, and preventive approaches.

Original languageEnglish (US)
Article number4220
JournalInternational journal of molecular sciences
Issue number17
StatePublished - Sep 1 2019


  • Animal model
  • Antibiotic resistance
  • Pneumonia
  • Pneumoniae
  • S
  • Vaccine

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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