Animal models of neurodegenerative diseases

Fabíola Mara Ribeiro, Elizabeth Ribeiro da Silva Camargos, Leonardo Cruz De Souza, Antonio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), increases with age, and the number of affected patients is expected to increase worldwide in the next decades. Accurately understanding the etiopathogenic mechanisms of these diseases is a crucial step for developing disease-modifying drugs able to preclude their emergence or at least slow their progression. Animal models contribute to increase the knowledge on the pathophysiology of neurodegenerative diseases. These models reproduce different aspects of a given disease, as well as the histopathological lesions and its main symptoms. The purpose of this review is to present the main animal models for AD, PD, and Huntington's disease.

Original languageEnglish (US)
Pages (from-to)S82-S91
JournalRevista Brasileira de Psiquiatria
Volume35
Issue numberSUPPL.2
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Animal models
  • Huntington's disease
  • Neurodegenerative diseases
  • Parkinson's disease

ASJC Scopus subject areas

  • Psychiatry and Mental health

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