Animal models of myocardial and vascular injury

Aaron M. Abarbanell, Jeremy L. Herrmann, Brent R. Weil, Yue Wang, Jiangning Tan, Steven P. Moberly, Jeremy W. Fiege, Daniel R. Meldrum

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


Over the past century, numerous animal models have been developed in an attempt to understand myocardial and vascular injury. However, the successful translation of results observed in animals to human therapy remains low. To understand this problem, we present several animal models of cardiac and vascular injury that are of particular relevance to the cardiac or vascular surgeon. We also explore the potential clinical implications and limitations of each model with respect to the human disease state. Our results underscore the concept that animal research requires an in-depth understanding of the model, animal physiology, and the potential confounding factors. Future outcome analyses with standardized animal models may improve translation of animal research from the bench to the bedside.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalJournal of Surgical Research
Issue number2
StatePublished - Aug 2010
Externally publishedYes


  • Animal models
  • Atherosclerosis
  • Comparative physiology
  • Endothelial damage
  • Heart failure
  • Ischemia/reperfusion
  • Myocardial infarction

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Animal models of myocardial and vascular injury'. Together they form a unique fingerprint.

Cite this