Abstract
Gynecological cancers develop in the reproductive organs of a woman. The common gynecological cancers are cervical, ovarian, uterine, vaginal, and vulvar cancers. Most of the gynecological cancers including the ovarian cancers undergo metastasis to distant organs, acquire resistance to cancer therapy, and relapse. There are no specific diagnostic biomarkers available to detect the early stages of gynecological cancers. The challenges to diagnose and treat gynecological cancers stem from the fact that these cancers are heterogeneous diseases and, therefore, need physiologically relevant animal model systems in order to develop strategies to discover targeted therapeutics. In this book chapter, the authors elaborate on mouse models that serve as helpful tools to understand the biology of gynecological cancers as well as the identification of biomarkers and novel therapeutics.
Original language | English (US) |
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Title of host publication | Handbook of Animal Models and its Uses in Cancer Research |
Publisher | Springer Nature |
Pages | 335-352 |
Number of pages | 18 |
ISBN (Electronic) | 9789811938245 |
ISBN (Print) | 9789811938238 |
DOIs | |
State | Published - Jan 1 2023 |
Keywords
- Animal model
- Cancer
- Endometrial cancer
- Gynecological cancer
- Ovarian cancer
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology