Animal Models of Gynecological Cancers

Prabhakar Pitta Venkata, Daisy Medina, Saif S.R. Nirzhor, Sivanandane Sittadjody, R. Ileng Kumaran, Ilangovan Ramachandran, Panneerdoss Subbarayalu

Research output: Chapter in Book/Report/Conference proceedingChapter


Gynecological cancers develop in the reproductive organs of a woman. The common gynecological cancers are cervical, ovarian, uterine, vaginal, and vulvar cancers. Most of the gynecological cancers including the ovarian cancers undergo metastasis to distant organs, acquire resistance to cancer therapy, and relapse. There are no specific diagnostic biomarkers available to detect the early stages of gynecological cancers. The challenges to diagnose and treat gynecological cancers stem from the fact that these cancers are heterogeneous diseases and, therefore, need physiologically relevant animal model systems in order to develop strategies to discover targeted therapeutics. In this book chapter, the authors elaborate on mouse models that serve as helpful tools to understand the biology of gynecological cancers as well as the identification of biomarkers and novel therapeutics.

Original languageEnglish (US)
Title of host publicationHandbook of Animal Models and its Uses in Cancer Research
PublisherSpringer Nature
Number of pages18
ISBN (Electronic)9789811938245
ISBN (Print)9789811938238
StatePublished - Jan 1 2023


  • Animal model
  • Cancer
  • Endometrial cancer
  • Gynecological cancer
  • Ovarian cancer

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


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