Animal models of bronchopulmonary dysplasia. The preterm baboon models

Bradley A. Yoder, Jacqueline J. Coalson

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we highlight how the preterm baboon model at both 140 and 125 days gestation (term equivalent 185 days) has advanced our understanding and management of the immature human infant with neonatal lung disease. Not only is the 125-day baboon model extremely relevant to the condition of bronchopulmonary dysplasia but there are also critical neurodevelopmental and other end-organ pathological features associated with this model not fully discussed in this limited forum. We also describe efforts to incorporate perinatal infection into these preterm models, both fetal and neonatal, and particularly associated with Ureaplasma/Mycoplasma organisms. Efforts to rekindle the preterm primate model for future evaluations of therapies such as stem cell replacement, early lung recruitment interventions coupled with noninvasive surfactant and high-frequency nasal ventilation, and surfactant therapy coupled with antioxidant or anti-inflammatory medications, to name a few, should be undertaken.

Original languageEnglish (US)
Pages (from-to)L970-L977
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume307
Issue number12
DOIs
StatePublished - Dec 15 2014

Keywords

  • Baboon
  • Bronchopulmonary dysplasia
  • Lung
  • Preterm infant
  • Ureaplasma

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

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