Animal models for brain tumors: historical perspectives and future directions

D. L. Peterson, P. J. Sheridan, W. E. Brown

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

The scientific understanding of the biology of human brain tumors has advanced in large part through the use of animal models. For most of this century, investigators have been evaluating the inciting factors in brain tumor development, and applying this knowledge to direct tumor growth in laboratory animals. Virus-induced, carcinogen-induced, and transplant-based models have been vigorously investigated. As knowledge of the molecular biology of neoplasia has advanced, transgenic technology has been introduced. The authors review the development of animal models for brain tumor, and focus on the role of transgenic models in elucidating the complex process of central nervous system neoplasia.

Original languageEnglish (US)
Pages (from-to)865-876
Number of pages12
JournalJournal of neurosurgery
Volume80
Issue number5
DOIs
StatePublished - 1994

Keywords

  • animal model
  • brain neoplasm
  • transgenic mouse

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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