Animal model of human disease. Smoke inhalation injury in sheep

G. B. Hubbard, T. Shimazu, T. Yukioka, P. C. Langlinais, A. D. Mason, B. A. Pruitt

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Pulmonary injury is influenced by smoke temperature, chemical and physical composition, contact time, and the surface area exposed. Although there are animal models of smoke inhalation available, no one model provides adequate body size, reproducibility, or controllable dose-response. The sheep model of inhalation injury is reproducible and dose-responsive. Additionally, the sheep model has many advantages, including ready availability, extensive definition, tractability, minimal emotional appeal, large size, innate hardiness, low cost, and tolerance to surgical and chemical manipulation.

Original languageEnglish (US)
Pages (from-to)660-663
Number of pages4
JournalAmerican Journal of Pathology
Issue number3
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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