Angiotensin II contributes to blood pressure maintenance in conscious rats treated with yohimbine

Sandra L. Pfister, T. Kent Keeton

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Yohimbine (1 mg/kg s.c.) produced significant and persistent increases in plasma renin concentration and plasma norepinephrine concentration in conscious rats, but mean arterial pressure (MAP) and heart rate were unchanged. The subsequent i.v. infusion of the angiotensin II receptor antagonist saralasin (100 μg/kg per min) caused a significant decrease (-17%) in MAP. We conclude that yohimbine-induced renin release, and the resultant rise in plasma angiotensin II concentration, prevents the decrease in MAP which would result from the blockade of vascular α-adrenoceptors by yohimbine.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalEuropean Journal of Pharmacology
Volume149
Issue number3
DOIs
StatePublished - May 10 1988
Externally publishedYes

Keywords

  • Mean arterial pressure (MAP)
  • Norepinephrine concentration (plasma)
  • Renin concentration (plasma)
  • Saralasin
  • Yohimbine
  • α-Adrenoceptors

ASJC Scopus subject areas

  • Pharmacology

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