Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy

Hernan Rincon-Choles, Balakuntalam S Kasinath, Yves Gorin, Hanna E. Abboud

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The renin-angiotensin system (RAS) and growth factors mediate structural and functional changes during the course of diabetic nephropathy (DN). Studies in humans and experimental models with DN suggest their involvement in the development and progression of DN. Activation of renal tissue RAS and increased expression of growth factors have been demonstrated at early stages of the disease. Angiotensin II and growth factors alter renal hemodynamics and exert trophic changes in renal cells that eventually result in fibrosis through direct mechanisms or through the release of other mediators. Their effects are likely modulated by metabolic changes including high glucose and free fatty acids. While blockade of the RAS ameliorates DN in humans, such evidence for blockade of growth factors is still lacking. It is likely that susceptibility to the development of DN and therapeutic efficacy are modulated by genetic polymorphisms in components of the RAS and growth factors including their receptors and other target molecules. Approaches to understand the intricate relationship between these systems and the mechanism(s) by which they alter capillary permeability and result in structural changes are areas of fruitful investigation.

Original languageEnglish (US)
JournalKidney International, Supplement
Volume62
Issue number82
StatePublished - 2002

Fingerprint

Diabetic Nephropathies
Angiotensin II
Intercellular Signaling Peptides and Proteins
Renin-Angiotensin System
Kidney
Capillary Permeability
Genetic Polymorphisms
Nonesterified Fatty Acids
Fibrosis
Theoretical Models
Hemodynamics
Glucose

Keywords

  • AGEs
  • Capillary permeability
  • Fibrosis
  • Hemodynamics
  • Progressive renal disease
  • Renin-angiotensin system
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Nephrology

Cite this

Rincon-Choles, H., Kasinath, B. S., Gorin, Y., & Abboud, H. E. (2002). Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy. Kidney International, Supplement, 62(82).

Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy. / Rincon-Choles, Hernan; Kasinath, Balakuntalam S; Gorin, Yves; Abboud, Hanna E.

In: Kidney International, Supplement, Vol. 62, No. 82, 2002.

Research output: Contribution to journalArticle

Rincon-Choles, H, Kasinath, BS, Gorin, Y & Abboud, HE 2002, 'Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy', Kidney International, Supplement, vol. 62, no. 82.
Rincon-Choles, Hernan ; Kasinath, Balakuntalam S ; Gorin, Yves ; Abboud, Hanna E. / Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy. In: Kidney International, Supplement. 2002 ; Vol. 62, No. 82.
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