TY - JOUR
T1 - Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia
AU - Gadelha, Ary
AU - Yonamine, Camila M.
AU - Nering, Marcela
AU - Rizzo, Lucas Bortolotto
AU - Noto, Cristiano
AU - Cogo-Moreira, Hugo
AU - Teixeira, Antônio Lúcio
AU - Bressan, Rodrigo
AU - Maes, Michael
AU - Brietzke, Elisa
AU - Hayashi, Mirian A.F.
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/10/30
Y1 - 2015/10/30
N2 - Previous studies of our group showed increased plasmatic Angiotensin-I Converting Enzyme (ACE) activity in schizophrenia (SCZ) patients compared to healthy controls, which was also associated to poor cognitive functioning. The ACE main product angiotensin II (Ang-II) has pro-inflammatory properties. Activated immune-inflammatory responses in SCZ and their association with disease progression and cognitive impairments are also well-described. Therefore, we examined here the association of plasma ACE activity and inflammatory mediators in 33 SCZ patients and 92 healthy controls. Non-parametric correlations were used to investigate the association of the enzyme activity and the peripheral levels of immune inflammatory markers as interleukins, tumor necrosis factor (TNF-α), and interferon (IFN-γ). Although no significant correlations could be observed for ACE activity and measured cytokines levels in healthy controls, a significant positive correlation for ACE enzymatic activity and IL-17a levels was observed in SCZ patients. Correcting for gender did not change these results. Moreover, a significant association for ACE activity and IFN-γ levels was also observed. To our knowledge, this is the first study to show a significant association between higher ACE activity and the levels of cytokines, namely IL-17a and IFN-γ, in patients with SCZ.
AB - Previous studies of our group showed increased plasmatic Angiotensin-I Converting Enzyme (ACE) activity in schizophrenia (SCZ) patients compared to healthy controls, which was also associated to poor cognitive functioning. The ACE main product angiotensin II (Ang-II) has pro-inflammatory properties. Activated immune-inflammatory responses in SCZ and their association with disease progression and cognitive impairments are also well-described. Therefore, we examined here the association of plasma ACE activity and inflammatory mediators in 33 SCZ patients and 92 healthy controls. Non-parametric correlations were used to investigate the association of the enzyme activity and the peripheral levels of immune inflammatory markers as interleukins, tumor necrosis factor (TNF-α), and interferon (IFN-γ). Although no significant correlations could be observed for ACE activity and measured cytokines levels in healthy controls, a significant positive correlation for ACE enzymatic activity and IL-17a levels was observed in SCZ patients. Correcting for gender did not change these results. Moreover, a significant association for ACE activity and IFN-γ levels was also observed. To our knowledge, this is the first study to show a significant association between higher ACE activity and the levels of cytokines, namely IL-17a and IFN-γ, in patients with SCZ.
KW - Angiotensin Converting Enzyme (ACE)
KW - Biomarker
KW - Cytokine
KW - Inflammation
KW - Inflammatory response
KW - Interleukin-17 (IL-17)
KW - Schizophrenia
UR - https://www.scopus.com/pages/publications/84941258751
UR - https://www.scopus.com/pages/publications/84941258751#tab=citedBy
U2 - 10.1016/j.psychres.2015.08.018
DO - 10.1016/j.psychres.2015.08.018
M3 - Article
C2 - 26296754
AN - SCOPUS:84941258751
SN - 0165-1781
VL - 229
SP - 702
EP - 707
JO - Psychiatry Research
JF - Psychiatry Research
IS - 3
M1 - 9159
ER -