Angiofollicular lymph node hyperplasia associated with myelofibrosis case report and immunologic marker studies

Ira J. Bleiweiss, Otilia L. Dumitrescu, Jaishree Jagirdar

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3 Scopus citations


A case of angiofollicular lymph node hyperplasia (AFH) (hyaline vascular type) of the mediastinum associated with myelofibrosis is reported with immune marker studies. We hypothesize that the myelofibrosis is more than a mere coincidence since other myeloproliferative disorders have been observed in conjunction with AFH. Immunohistochemistry on cryostat sections of lymph node using the biotin‐avidin fluorescence technique showed the presence of numerous T helper cells and very few T suppressor/cytotoxic cells in the parafollicular areas. Concentric rings of lymphocytes showed the phenotype of mantle zone lymphocytes (i.e. IgM, IgD positivity), while the germinal centres were ill‐formed as shown by Leu 14 (a Pan B cell marker) staining. By electron microscopy, follicular dendritic reticulum cells were readily found. The above findings suggest an abnormality of germinal center formation.

Original languageEnglish (US)
Pages (from-to)275-284
Number of pages10
JournalHematological Oncology
Issue number4
StatePublished - Jan 1 1988



  • Angiofollicular lymph node hyperplasia
  • Castleman's disease
  • Immunopathology
  • Myelofibrosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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