Angiofollicular lymph node hyperplasia associated with myelofibrosis case report and immunologic marker studies

I. J. Bleiweiss, O. L. Dumitrescu, J. Jagirdar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A case of angiofollicular lymph node hyperplasia (AFH) (hyaline vascular type) of the mediastinum associated with myelofibrosis is reported with immune marker studies. We hypothesize that the myelofibrosis is more than a mere coincidence since other myeloproliferative disorders have been observed in conjunction with AFH. Immunohistochemistry on cryostat sections of lymph node using the biotin-avidin fluorescence technique showed the presence of numerous T helper cells and very few T suppressor/cytotoxic cells in the parafollicular areas. Concentric rings of lymphocytes showed the phenotype of mantle zone lymphocytes (i.e. IgM, IgD positivity), while the germinal centres were ill-formed as shown by Leu 14 (a Pan B cell marker) staining. By electron microscopy, follicular dendritic reticulum cells were readily found. The above findings suggest an abnormality of germinal center formation.

Original languageEnglish (US)
Pages (from-to)275-284
Number of pages10
JournalHematological Oncology
Volume6
Issue number4
StatePublished - 1988
Externally publishedYes

Fingerprint

Giant Lymph Node Hyperplasia
Primary Myelofibrosis
Germinal Center
Biomarkers
Lymphocytes
Follicular Dendritic Cells
Immunoglobulin D
Myeloproliferative Disorders
Hyalin
Avidin
Mediastinum
Biotin
Helper-Inducer T-Lymphocytes
Immunoglobulin M
Blood Vessels
Electron Microscopy
B-Lymphocytes
Fluorescence
Lymph Nodes
Immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Angiofollicular lymph node hyperplasia associated with myelofibrosis case report and immunologic marker studies. / Bleiweiss, I. J.; Dumitrescu, O. L.; Jagirdar, J.

In: Hematological Oncology, Vol. 6, No. 4, 1988, p. 275-284.

Research output: Contribution to journalArticle

Bleiweiss, I. J. ; Dumitrescu, O. L. ; Jagirdar, J. / Angiofollicular lymph node hyperplasia associated with myelofibrosis case report and immunologic marker studies. In: Hematological Oncology. 1988 ; Vol. 6, No. 4. pp. 275-284.
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