Aneuploidy, an early event in mouse skin tumor development

Claudio J. Conti, Claudio M. Aldaz, John O'connell, Andres J p Klein-szanto, Thomas J Slaga

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

It has been suggested that chromosomal alterations can play a role in mouse skin carcinogenesis. These changes have been proposed as a possible mechanism of action of tumor promoters and they have also been related to the conversion of benign papillomas to carcinomas. However, direct evidence showing the chromosomal constitution of these tumors has not been previously described. Here we show the presence of aneuploid cells in very early papillomas and the eventual displacement of the diploid stem line by aneuploid clones at later stages. Squamous cell carcinomas (SCC) induced by the same protocol were highly aneuploid. These results suggest that genomic imbalance produced by aneuploidy may be related to the malignant conversion of the benign papillomas.

Original languageEnglish (US)
Pages (from-to)1845-1848
Number of pages4
JournalCarcinogenesis
Volume7
Issue number11
DOIs
StatePublished - Nov 1986
Externally publishedYes

Fingerprint

Aneuploidy
Skin
Mouse
Tumors
Tumor
Papilloma
Carcinogenesis
Cell
Clone
Promoter
Genomics
Neoplasms
Line
Constitution and Bylaws
Diploidy
Carcinogens
Squamous Cell Carcinoma
Clone Cells
Carcinoma
Evidence

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

Cite this

Conti, C. J., Aldaz, C. M., O'connell, J., Klein-szanto, A. J. P., & Slaga, T. J. (1986). Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis, 7(11), 1845-1848. https://doi.org/10.1093/carcin/7.11.1845

Aneuploidy, an early event in mouse skin tumor development. / Conti, Claudio J.; Aldaz, Claudio M.; O'connell, John; Klein-szanto, Andres J p; Slaga, Thomas J.

In: Carcinogenesis, Vol. 7, No. 11, 11.1986, p. 1845-1848.

Research output: Contribution to journalArticle

Conti, CJ, Aldaz, CM, O'connell, J, Klein-szanto, AJP & Slaga, TJ 1986, 'Aneuploidy, an early event in mouse skin tumor development', Carcinogenesis, vol. 7, no. 11, pp. 1845-1848. https://doi.org/10.1093/carcin/7.11.1845
Conti, Claudio J. ; Aldaz, Claudio M. ; O'connell, John ; Klein-szanto, Andres J p ; Slaga, Thomas J. / Aneuploidy, an early event in mouse skin tumor development. In: Carcinogenesis. 1986 ; Vol. 7, No. 11. pp. 1845-1848.
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