Androgenic induction of α2u-globulin in the rat: Requirement of an intact pituitary

Mahendra Kumar; Arun K. Roy; A. E. Axelrod

doi:10.1038/223399a0

Androgenic induction of α_2u-globulin in the rat: Requirement of an intact pituitary

Mahendra Kumar, Arun K. Roy, A. E. Axelrod

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Abstract

A SEX dependent urinary protein in the rat has been described by Roy and Neuhaus^1-4. This protein is an α₂-globulin (α_2U) of hepatic origin and has a molecular weight of 26,400 (refs. 2 and 3). It is rapidly excreted in the urine³. The level of α_2U in blood is therefore very low (< 3 mg per 100 ml. blood)³. This protein is absent in females and immature male rats. The synthesis of α_2U is very sensitive to hormonal manipulations⁴. Treatment with testosterone of the spayed females induces its synthesis whereas treatment of adult male rats with oestradiol brings about a complete repression⁴. A quantitative immunological method for the assay of α_2U has been described³. All of these above mentioned properties make α_2U a very convenient system for studying the possible hormonal control of gene action in the mammalian system. In this communication we report our studies on the requirement of the pituitary gland for the androgenic induction of α_2U in spayed rats.

Original language	English (US)
Pages (from-to)	399-400
Number of pages	2
Journal	Nature
Volume	223
Issue number	5204
DOIs	https://doi.org/10.1038/223399a0
State	Published - 1969
Externally published	Yes

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@article{bca348059e5d4399a4888813f6ca5c5a,

title = "Androgenic induction of α2u-globulin in the rat: Requirement of an intact pituitary",

abstract = "A SEX dependent urinary protein in the rat has been described by Roy and Neuhaus1-4. This protein is an α2-globulin (α2U) of hepatic origin and has a molecular weight of 26,400 (refs. 2 and 3). It is rapidly excreted in the urine3. The level of α2U in blood is therefore very low (< 3 mg per 100 ml. blood)3. This protein is absent in females and immature male rats. The synthesis of α2U is very sensitive to hormonal manipulations4. Treatment with testosterone of the spayed females induces its synthesis whereas treatment of adult male rats with oestradiol brings about a complete repression4. A quantitative immunological method for the assay of α2U has been described3. All of these above mentioned properties make α2U a very convenient system for studying the possible hormonal control of gene action in the mammalian system. In this communication we report our studies on the requirement of the pituitary gland for the androgenic induction of α2U in spayed rats.",

author = "Mahendra Kumar and Roy, {Arun K.} and Axelrod, {A. E.}",

year = "1969",

doi = "10.1038/223399a0",

language = "English (US)",

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pages = "399--400",

journal = "Nature",

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publisher = "Nature Publishing Group",

number = "5204",

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TY - JOUR

T1 - Androgenic induction of α2u-globulin in the rat

T2 - Requirement of an intact pituitary

AU - Kumar, Mahendra

AU - Roy, Arun K.

AU - Axelrod, A. E.

PY - 1969

Y1 - 1969

N2 - A SEX dependent urinary protein in the rat has been described by Roy and Neuhaus1-4. This protein is an α2-globulin (α2U) of hepatic origin and has a molecular weight of 26,400 (refs. 2 and 3). It is rapidly excreted in the urine3. The level of α2U in blood is therefore very low (< 3 mg per 100 ml. blood)3. This protein is absent in females and immature male rats. The synthesis of α2U is very sensitive to hormonal manipulations4. Treatment with testosterone of the spayed females induces its synthesis whereas treatment of adult male rats with oestradiol brings about a complete repression4. A quantitative immunological method for the assay of α2U has been described3. All of these above mentioned properties make α2U a very convenient system for studying the possible hormonal control of gene action in the mammalian system. In this communication we report our studies on the requirement of the pituitary gland for the androgenic induction of α2U in spayed rats.

AB - A SEX dependent urinary protein in the rat has been described by Roy and Neuhaus1-4. This protein is an α2-globulin (α2U) of hepatic origin and has a molecular weight of 26,400 (refs. 2 and 3). It is rapidly excreted in the urine3. The level of α2U in blood is therefore very low (< 3 mg per 100 ml. blood)3. This protein is absent in females and immature male rats. The synthesis of α2U is very sensitive to hormonal manipulations4. Treatment with testosterone of the spayed females induces its synthesis whereas treatment of adult male rats with oestradiol brings about a complete repression4. A quantitative immunological method for the assay of α2U has been described3. All of these above mentioned properties make α2U a very convenient system for studying the possible hormonal control of gene action in the mammalian system. In this communication we report our studies on the requirement of the pituitary gland for the androgenic induction of α2U in spayed rats.

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IS - 5204

ER -

Androgenic induction of α_2u-globulin in the rat: Requirement of an intact pituitary

Abstract

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