Androgenic control of N‐acetyltransferase activity in the harderian glands of the syrian hamster is mediated by 5α‐dihydrotestosterone

Armando Menendez‐Pelaez, Gerald R. Buzzell, Aldo Gonzaiez‐Brito, Russel J. Reiter

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

N‐acetyltransferase (NAT) activity in the Harderian glands of intact and gonadectomized male and female Syrian hamsters was evaluated. The exogenous administration of 5α‐dihydrotestosterone (DHT) to castrated males and intact females produced an increase in NAT values, which reached the values present in the glands of intact males. The administration of a 5α‐reductase inhibitor to intact males led to a decrease in NAT activity, suggesting that testosterone is converted in DHT within the glands. It is concluded that NAT activity in the Syrian hamster Harderian glands is under androgenic control, the active steroid being DHT.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalJournal of Cellular Biochemistry
Volume42
Issue number2
DOIs
StatePublished - Feb 1990

Keywords

  • 5α‐reductase
  • DHT
  • NAT
  • androgens
  • steroids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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