Androgenic control of N-acetyltransferase activity in the Harderian glands of the Syrian hamster is mediated by 5α-dihydrotestosterone

A. Menendez-Pelaez, G. R. Buzzell, A. Gonzalez-Brito, Russel J Reiter

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

N-acetyltransferase (NAT) activity in the Harderian glands of intact and gonadectomized male and female Syrian hamsters was evaluated. The exogenous administration of 5α-dihydrotestosterone (DHT) to castrated males and intact females produced an increase in NAT values, which reached the values present in the glands of intact males. The administration of a 5α-reductase inhibitor to intact males led to a decrease in NAT activity, suggesting that testosterone is converted in DHT within the glands. It is concluded that NAT activity in the Syrian hamster Harderian glands is under androgenic control, the active steroid being DHT.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalJournal of Cellular Biochemistry
Volume42
Issue number2
StatePublished - 1990

Fingerprint

Harderian Gland
Acetyltransferases
Dihydrotestosterone
Mesocricetus
Testosterone
Oxidoreductases
Steroids

Keywords

  • 5α-reductase
  • Androgens
  • DHT
  • NAT
  • Steroids

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Androgenic control of N-acetyltransferase activity in the Harderian glands of the Syrian hamster is mediated by 5α-dihydrotestosterone. / Menendez-Pelaez, A.; Buzzell, G. R.; Gonzalez-Brito, A.; Reiter, Russel J.

In: Journal of Cellular Biochemistry, Vol. 42, No. 2, 1990, p. 95-100.

Research output: Contribution to journalArticle

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