Androgen receptor in the rat liver: correlation between cytosol receptor activity and androgen dependent synthesis of α2 globulin

A. K. Roy, B. Milin, D. McMinn, W. L. Wilson

Research output: Contribution to journalArticlepeer-review

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Abstract

In pursuance of mechanism on the muchanism of the androgen dependent synthesis of α(2u) globulin in rat liver the authors have recently discovered a specific androgen receptor in the hepatic cytosol. The receptor is protein in nature and has a sedimentation coefficient of 3.5 S. The receptor protein binds with 5α dihydrotestosterone (DHT), testosterone, and androstanediol with a decreasing order of affinity. Analysis of the DHT binding data on a Scatchard plot yields an approximate dissociation constant of 2.4x10-8M. A strong correlation between the hepatic cytosol androgen receptor (HCAR) activity and the synthesis of α(2u) globulin was also established HCAR activity could only be found in the mature male rats which normally produce α(2u) globulin. HCAR could not be detected in the immature male, female, and pseudohermaphrodite male rats which do not synthesize α(2u) globulin. Androgen treatment to sensitive animals was found to induce HCAR and subsequently α(2u) globulin.

Original languageEnglish (US)
Pages (from-to)461
Number of pages1
JournalFederation Proceedings
Volume32
Issue number3 (I)
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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