Androgen receptor CAG repeat length and TMPRSS2:ETS prostate cancer risk: Results from the prostate cancer prevention trial

William D. Figg, Cindy H. Chau, Douglas K. Price, Cathee Till, Phyllis J. Goodman, Yonggon Cho, Marileila Varella-Garcia, Juergen K.V. Reichardt, Catherine M. Tangen, Robin J. Leach, Adrie Van Bokhoven, Ian M. Thompson, M. Scott Lucia

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective To investigate the association between the length of the polymorphic trinucleotide CAG microsatellite repeats in exon 1 of the AR gene and the risk of prostate cancer containing TMPRSS2:ETS fusion genes. Methods This nested case-control study came from subjects enrolled in the Prostate Cancer Prevention Trial and included 195 biopsy-proven prostate cancer cases with a known TMPRSS2:ETS status and 1344 matched controls. Results There was no association between the CAG repeat length and the risk of TMPRSS2:ETS-positive (odds ratio, 0.97; 95% confidence interval, 0.91-1.04) or TMPRSS2:ETS-negative prostate cancer (odds ratio, 1.04; 95% confidence interval, 0.97-1.11) and in patients with low- or high-grade disease. Conclusion Our findings suggested that AR CAG repeats are not associated with TMPRSS2:ETS formation in prostate cancer.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalUrology
Volume84
Issue number1
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Urology

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    Figg, W. D., Chau, C. H., Price, D. K., Till, C., Goodman, P. J., Cho, Y., Varella-Garcia, M., Reichardt, J. K. V., Tangen, C. M., Leach, R. J., Van Bokhoven, A., Thompson, I. M., & Lucia, M. S. (2014). Androgen receptor CAG repeat length and TMPRSS2:ETS prostate cancer risk: Results from the prostate cancer prevention trial. Urology, 84(1), 127-131. https://doi.org/10.1016/j.urology.2014.03.015