Abstract
Cloning of the androgen and estrogen sulfotransferases has allowed studies on their spatio-temporal regulation and physiological function. These two enzymes appear to be involved in regulating target cell sensitivity for the androgenic and estrogenic steroids. Recombinant androgen sulfotransferase produced in insect Sf9 cells through a baculoviral expression vector is capable of transferring the sulfate from PAPS (phosphoadenosine phosphosulfate) to 3α, 3β, 17α, and 17β hydroxyl groups of a number of steroid substrates indicating a broad range of substrate specificity.
Original language | English (US) |
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Pages (from-to) | 273-279 |
Number of pages | 7 |
Journal | Chemico-Biological Interactions |
Volume | 92 |
Issue number | 1-3 |
DOIs | |
State | Published - Jun 1994 |
Keywords
- Aging
- Baculoviral expression
- Liver
- Recombinant sulfotransfersae
- Sex hormone action
- Steroid sulfotransferase
ASJC Scopus subject areas
- Toxicology