Androgen and estrogen sulfotransferases of the rat liver: physiological function, molecular cloning, and in vitro expression

B. Chatterjee, C. S. Song, J. M. Kim, A. K. Roy

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Cloning of the androgen and estrogen sulfotransferases has allowed studies on their spatio-temporal regulation and physiological function. These two enzymes appear to be involved in regulating target cell sensitivity for the androgenic and estrogenic steroids. Recombinant androgen sulfotransferase produced in insect Sf9 cells through a baculoviral expression vector is capable of transferring the sulfate from PAPS (phosphoadenosine phosphosulfate) to 3α, 3β, 17α, and 17β hydroxyl groups of a number of steroid substrates indicating a broad range of substrate specificity.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalChemico-Biological Interactions
Volume92
Issue number1-3
DOIs
StatePublished - Jun 1994

Keywords

  • Aging
  • Baculoviral expression
  • Liver
  • Recombinant sulfotransfersae
  • Sex hormone action
  • Steroid sulfotransferase

ASJC Scopus subject areas

  • Toxicology

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