Ancestry informative markers and admixture proportions in northeastern Mexico

Margarita L. Martinez-Fierro, Joke Beuten, Robin J. Leach, Esteban J. Parra, Miguel Cruz-Lopez, Hector Rangel-Villalobos, Lina R. Riego-Ruiz, Rocio Ortiz-Lopez, Herminia G. Martinez-Rodriguez, Augusto Rojas-Martinez

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

To investigate the ancestral admixture in the Mestizo population in northeastern Mexico, we genotyped 74 ancestral informative markers (AIMs) and 15 Y-single-nucleotide polymorphisms (Y-SNPs) in 100 individuals. The Native American contribution is 56% (range: 27.4-81.2%), the European contribution is 38% (range: 16.7-70.5%) and the West African contribution is 6%. The results show a higher European contribution than was reported in other similar studies in the country, albeit with a predominant Native American ancestry. No remarkable differences in the ancestry proportions were observed using subgroups of 74, 54, 34 and 24 AIMs. The paternal lineage calculated by genotyping of 15 Y-SNPs, shows a major component of European and Eurasian ancestry markers (78%), compared with Amerindian (12%) and African markers (10%). This information will set a reference for future determinations of admixture proportions in the Mestizo population from Mexico and for population-based association studies of complex diseases.

Original languageEnglish (US)
Pages (from-to)504-509
Number of pages6
JournalJournal of Human Genetics
Volume54
Issue number9
DOIs
StatePublished - Sep 2009

Keywords

  • AIMs
  • Admixture
  • Ancestry
  • Markers
  • Population
  • Y-SNPs

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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