Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression

Sheila C. Caetano, John P. Hatch, Paolo Brambilla, Roberto B. Sassi, Mark Nicoletti, Alan G. Mallinger, Ellen Frank, David J. Kupfer, Matcheri S. Keshavan, Jair C. Soares

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Morphometric MRI studies suggest decreased hippocampal volumes in currently depressed patients, with conflicting findings for the amygdala. We studied these temporal lobe structures and superior temporal gyrus (STG) in patients with current and remitted major depression. We scanned 31 unmedicated depressed patients (21 currently depressed, 10 remitted) and 31 matched healthy controls with a 3D SPGR sequence in a 1.5 Tesla GE Signa Imaging System. There was a trend towards smaller left amygdala volumes in all depressed patients compared with healthy controls. We found significantly smaller hippocampal volumes bilaterally in currently depressed patients than in remitted patients. Furthermore, we found a statistically significant inverse correlation between length of illness and left hippocampus volumes and right superior temporal gyrus volumes. Our finding of smaller hippocampi in currently depressed patients is consistent with the hypothesis that hypercortisolism could result in hippocampal neurotoxicity in major depression. A smaller hippocampal size may be more characteristic of the depressive state and not be present in remitted patients.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume132
Issue number2
DOIs
StatePublished - Dec 15 2004

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Amygdala
Hippocampus
Temporal Lobe
Cushing Syndrome

Keywords

  • Amygdala
  • Depression
  • Hippocampus
  • MRI
  • Neuroimaging
  • Superior temporal gyrus
  • Temporal lobe

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Caetano, S. C., Hatch, J. P., Brambilla, P., Sassi, R. B., Nicoletti, M., Mallinger, A. G., ... Soares, J. C. (2004). Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression. Psychiatry Research - Neuroimaging, 132(2), 141-147. https://doi.org/10.1016/j.pscychresns.2004.08.002

Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression. / Caetano, Sheila C.; Hatch, John P.; Brambilla, Paolo; Sassi, Roberto B.; Nicoletti, Mark; Mallinger, Alan G.; Frank, Ellen; Kupfer, David J.; Keshavan, Matcheri S.; Soares, Jair C.

In: Psychiatry Research - Neuroimaging, Vol. 132, No. 2, 15.12.2004, p. 141-147.

Research output: Contribution to journalArticle

Caetano, SC, Hatch, JP, Brambilla, P, Sassi, RB, Nicoletti, M, Mallinger, AG, Frank, E, Kupfer, DJ, Keshavan, MS & Soares, JC 2004, 'Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression', Psychiatry Research - Neuroimaging, vol. 132, no. 2, pp. 141-147. https://doi.org/10.1016/j.pscychresns.2004.08.002
Caetano, Sheila C. ; Hatch, John P. ; Brambilla, Paolo ; Sassi, Roberto B. ; Nicoletti, Mark ; Mallinger, Alan G. ; Frank, Ellen ; Kupfer, David J. ; Keshavan, Matcheri S. ; Soares, Jair C. / Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression. In: Psychiatry Research - Neuroimaging. 2004 ; Vol. 132, No. 2. pp. 141-147.
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