Anatomical manifestations of primary blast ocular trauma observed in a postmortem porcine model

Daniel Sherwood, William E. Sponsel, Brian J. Lund, Walt Gray, Richard Watson, Sylvia L. Groth, Kimberly Thoe, Randolph D. Glickman, Matthew A. Reilly

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Purpose. We qualitatively describe the anatomic features of primary blast ocular injury observed using a postmortem porcine eye model. Porcine eyes were exposed to various levels of blast energy to determine the optimal conditions for future testing. Methods. We studied 53 enucleated porcine eyes: 13 controls and 40 exposed to a range of primary blast energy levels. Eyes were preassessed with B-scan and ultrasound biomicroscopy (UBM) ultrasonography, photographed, mounted in gelatin within acrylic orbits, and monitored with high-speed videography during blast-tube impulse exposure. Postimpact photography, ultrasonography, and histopathology were performed, and ocular damage was assessed. Results. Evidence for primary blast injury was obtained. While some of the same damage was observed in the control eyes, the incidence and severity of this damage in exposed eyes increased with impulse and peak pressure, suggesting that primary blast exacerbated these injuries. Common findings included angle recession, internal scleral delamination, cyclodialysis, peripheral chorioretinal detachments, and radial peripapillary retinal detachments. No full-thickness openings of the eyewall were observed in any of the eyes tested. Scleral damage demonstrated the strongest associative tendency for increasing likelihood of injury with increased overpressure. Conclusions. These data provide evidence that primary blast alone (in the absence of particle impact) can produce clinically relevant ocular damage in a postmortem model. The blast parameters derived from this study are being used currently in an in vivo model. We also propose a new Cumulative Injury Score indicating the clinical relevance of observed injuries.

Original languageEnglish (US)
Pages (from-to)1124-1132
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number2
DOIs
StatePublished - Jan 28 2014

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Keywords

  • Blast impact
  • Histopathology
  • Primary blast injury
  • Trauma
  • Ultrabiomicroscopy (UBM)

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Sherwood, D., Sponsel, W. E., Lund, B. J., Gray, W., Watson, R., Groth, S. L., Thoe, K., Glickman, R. D., & Reilly, M. A. (2014). Anatomical manifestations of primary blast ocular trauma observed in a postmortem porcine model. Investigative Ophthalmology and Visual Science, 55(2), 1124-1132. https://doi.org/10.1167/iovs.13-13295