Anastomotic leak detection by electrolyte electrical resistance

Daniel T Dearmond, Adam M. Cline, Scott B Johnson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To characterize a new method of postoperative gastrointestinal leak detection based on electrical resistance changes due to extravasated electrolyte contrast. Background: Postoperative gastrointestinal leak results in increased patient morbidity, mortality, and hospital costs that can be mitigated by early diagnosis. A sensitive and specific diagnostic test that could be performed at the bedside has the potential to shorten the time to diagnosis and thereby improve the quality of treatment. Materials and Methods: Anaesthetized rats underwent celiotomy and creation of a 5-mm gastrotomy. In experimental animals, electrical resistance changes were measured with a direct current ohmmeter after the introduction of 5 cc of 23.4 NaCl electrolyte solution via gavage and measured with a more sensitive alternating current ohmmeter after the gavage of 15 cc of 0.9 NaCl. Comparison was made to negative controls and statistical analysis was performed. Results: Leakage from the gastrotomy induced by as little as 1 cc of gavage-delivered 0.9 NaCl contrast solution was detectable as a statistically significant drop in electrical resistance when compared to results from negative controls. Conclusion: Electrical resistance change associated with electrolyte-gated leak detection is highly sensitive and specific and has the potential to be rapidly translated into clinical settings.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalJournal of Investigative Surgery
Volume23
Issue number4
DOIs
StatePublished - Jul 2010

Fingerprint

Anastomotic Leak
Electric Impedance
Electrolytes
Hospital Costs
Routine Diagnostic Tests
Early Diagnosis
Morbidity
Mortality
Therapeutics

Keywords

  • Anastomotic leak
  • Bioimpedance
  • Esophageal surgery
  • Gastrointestinal surgery
  • Postoperative complications
  • Quality assurance

ASJC Scopus subject areas

  • Surgery

Cite this

Anastomotic leak detection by electrolyte electrical resistance. / Dearmond, Daniel T; Cline, Adam M.; Johnson, Scott B.

In: Journal of Investigative Surgery, Vol. 23, No. 4, 07.2010, p. 197-203.

Research output: Contribution to journalArticle

Dearmond, Daniel T ; Cline, Adam M. ; Johnson, Scott B. / Anastomotic leak detection by electrolyte electrical resistance. In: Journal of Investigative Surgery. 2010 ; Vol. 23, No. 4. pp. 197-203.
@article{222fc993020a4cab8ab6308f8c78963f,
title = "Anastomotic leak detection by electrolyte electrical resistance",
abstract = "Objective: To characterize a new method of postoperative gastrointestinal leak detection based on electrical resistance changes due to extravasated electrolyte contrast. Background: Postoperative gastrointestinal leak results in increased patient morbidity, mortality, and hospital costs that can be mitigated by early diagnosis. A sensitive and specific diagnostic test that could be performed at the bedside has the potential to shorten the time to diagnosis and thereby improve the quality of treatment. Materials and Methods: Anaesthetized rats underwent celiotomy and creation of a 5-mm gastrotomy. In experimental animals, electrical resistance changes were measured with a direct current ohmmeter after the introduction of 5 cc of 23.4 NaCl electrolyte solution via gavage and measured with a more sensitive alternating current ohmmeter after the gavage of 15 cc of 0.9 NaCl. Comparison was made to negative controls and statistical analysis was performed. Results: Leakage from the gastrotomy induced by as little as 1 cc of gavage-delivered 0.9 NaCl contrast solution was detectable as a statistically significant drop in electrical resistance when compared to results from negative controls. Conclusion: Electrical resistance change associated with electrolyte-gated leak detection is highly sensitive and specific and has the potential to be rapidly translated into clinical settings.",
keywords = "Anastomotic leak, Bioimpedance, Esophageal surgery, Gastrointestinal surgery, Postoperative complications, Quality assurance",
author = "Dearmond, {Daniel T} and Cline, {Adam M.} and Johnson, {Scott B}",
year = "2010",
month = "7",
doi = "10.3109/08941930903469458",
language = "English (US)",
volume = "23",
pages = "197--203",
journal = "Journal of Investigative Surgery",
issn = "0894-1939",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Anastomotic leak detection by electrolyte electrical resistance

AU - Dearmond, Daniel T

AU - Cline, Adam M.

AU - Johnson, Scott B

PY - 2010/7

Y1 - 2010/7

N2 - Objective: To characterize a new method of postoperative gastrointestinal leak detection based on electrical resistance changes due to extravasated electrolyte contrast. Background: Postoperative gastrointestinal leak results in increased patient morbidity, mortality, and hospital costs that can be mitigated by early diagnosis. A sensitive and specific diagnostic test that could be performed at the bedside has the potential to shorten the time to diagnosis and thereby improve the quality of treatment. Materials and Methods: Anaesthetized rats underwent celiotomy and creation of a 5-mm gastrotomy. In experimental animals, electrical resistance changes were measured with a direct current ohmmeter after the introduction of 5 cc of 23.4 NaCl electrolyte solution via gavage and measured with a more sensitive alternating current ohmmeter after the gavage of 15 cc of 0.9 NaCl. Comparison was made to negative controls and statistical analysis was performed. Results: Leakage from the gastrotomy induced by as little as 1 cc of gavage-delivered 0.9 NaCl contrast solution was detectable as a statistically significant drop in electrical resistance when compared to results from negative controls. Conclusion: Electrical resistance change associated with electrolyte-gated leak detection is highly sensitive and specific and has the potential to be rapidly translated into clinical settings.

AB - Objective: To characterize a new method of postoperative gastrointestinal leak detection based on electrical resistance changes due to extravasated electrolyte contrast. Background: Postoperative gastrointestinal leak results in increased patient morbidity, mortality, and hospital costs that can be mitigated by early diagnosis. A sensitive and specific diagnostic test that could be performed at the bedside has the potential to shorten the time to diagnosis and thereby improve the quality of treatment. Materials and Methods: Anaesthetized rats underwent celiotomy and creation of a 5-mm gastrotomy. In experimental animals, electrical resistance changes were measured with a direct current ohmmeter after the introduction of 5 cc of 23.4 NaCl electrolyte solution via gavage and measured with a more sensitive alternating current ohmmeter after the gavage of 15 cc of 0.9 NaCl. Comparison was made to negative controls and statistical analysis was performed. Results: Leakage from the gastrotomy induced by as little as 1 cc of gavage-delivered 0.9 NaCl contrast solution was detectable as a statistically significant drop in electrical resistance when compared to results from negative controls. Conclusion: Electrical resistance change associated with electrolyte-gated leak detection is highly sensitive and specific and has the potential to be rapidly translated into clinical settings.

KW - Anastomotic leak

KW - Bioimpedance

KW - Esophageal surgery

KW - Gastrointestinal surgery

KW - Postoperative complications

KW - Quality assurance

UR - http://www.scopus.com/inward/record.url?scp=77955444542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955444542&partnerID=8YFLogxK

U2 - 10.3109/08941930903469458

DO - 10.3109/08941930903469458

M3 - Article

C2 - 20690844

AN - SCOPUS:77955444542

VL - 23

SP - 197

EP - 203

JO - Journal of Investigative Surgery

JF - Journal of Investigative Surgery

SN - 0894-1939

IS - 4

ER -