Anaphylactoid reactions to iodinated contrast material

Philip Lieberman, Robert L. Siegle, William W. Taylor

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


A review of the literature involving anaphylactoid reactions to iodinated contrast material (ICM) suggests that the reactions are nonantibody-mediated but that a complex activation of inflammatory mediators occurs. Histamine release and/or complement activation has been demonstrated in both in vitro and in vivo experimental systems. It appears that pretreatment of selected cases (those patients previously exhibiting an anaphylactoid reaction) is effective in reducing the frequency and seventy of subsequent reactions when readministration is necessary.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Issue number3
StatePublished - Sep 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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