Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis

Dagmar Koethe; Andrea Giuffrida; Daniela Schreiber; Martin Hellmich; Frauke Schultze-Lutter; Stefan Ruhrmann; Joachim Klosterkotter; Daniefe Piomelli; F. Markus Leweke

doi:10.1192/bjp.bp.108.053843

Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis

Dagmar Koethe, Andrea Giuffrida, Daniela Schreiber, Martin Hellmich, Frauke Schultze-Lutter, Stefan Ruhrmann, Joachim Klosterkotter, Daniefe Piomelli, F. Markus Leweke

Pharmacology

Research output: Contribution to journal › Article

106 Scopus citations

Abstract

Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=8D using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.

Original language	English (US)
Pages (from-to)	371-372
Number of pages	2
Journal	British Journal of Psychiatry
Volume	194
Issue number	4
DOIs	https://doi.org/10.1192/bjp.bp.108.053843
State	Published - Apr 1 2009

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ASJC Scopus subject areas

Psychiatry and Mental health

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Koethe, D., Giuffrida, A., Schreiber, D., Hellmich, M., Schultze-Lutter, F., Ruhrmann, S., Klosterkotter, J., Piomelli, D., & Leweke, F. M. (2009). Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. British Journal of Psychiatry, 194(4), 371-372. https://doi.org/10.1192/bjp.bp.108.053843

Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. / Koethe, Dagmar; Giuffrida, Andrea; Schreiber, Daniela; Hellmich, Martin; Schultze-Lutter, Frauke; Ruhrmann, Stefan; Klosterkotter, Joachim; Piomelli, Daniefe; Leweke, F. Markus.

In: British Journal of Psychiatry, Vol. 194, No. 4, 01.04.2009, p. 371-372.

Research output: Contribution to journal › Article

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10.1192/bjp.bp.108.053843