TY - JOUR
T1 - Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis
AU - Koethe, Dagmar
AU - Giuffrida, Andrea
AU - Schreiber, Daniela
AU - Hellmich, Martin
AU - Schultze-Lutter, Frauke
AU - Ruhrmann, Stefan
AU - Klosterkotter, Joachim
AU - Piomelli, Daniefe
AU - Leweke, F. Markus
PY - 2009/4
Y1 - 2009/4
N2 - Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=8D using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.
AB - Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=8D using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.
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U2 - 10.1192/bjp.bp.108.053843
DO - 10.1192/bjp.bp.108.053843
M3 - Article
C2 - 19336792
AN - SCOPUS:64149127015
VL - 194
SP - 371
EP - 372
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - 4
ER -