Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis

Dagmar Koethe; Andrea Giuffrida; Daniela Schreiber; Martin Hellmich; Frauke Schultze-Lutter; Stefan Ruhrmann; Joachim Klosterkotter; Daniefe Piomelli; F. Markus Leweke

doi:10.1192/bjp.bp.108.053843

Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis

Dagmar Koethe, Andrea Giuffrida, Daniela Schreiber, Martin Hellmich, Frauke Schultze-Lutter, Stefan Ruhrmann, Joachim Klosterkotter, Daniefe Piomelli, F. Markus Leweke

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119 Scopus citations

Abstract

Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=8D using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.

Original language	English (US)
Pages (from-to)	371-372
Number of pages	2
Journal	British Journal of Psychiatry
Volume	194
Issue number	4
DOIs	https://doi.org/10.1192/bjp.bp.108.053843
State	Published - Apr 2009
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

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abstract = "Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=8D using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.",

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AU - Koethe, Dagmar

AU - Giuffrida, Andrea

AU - Schreiber, Daniela

AU - Hellmich, Martin

AU - Schultze-Lutter, Frauke

AU - Ruhrmann, Stefan

AU - Klosterkotter, Joachim

AU - Piomelli, Daniefe

AU - Leweke, F. Markus

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AB - Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=8D using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.

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Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis

Abstract

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