BACKGROUND: Identification of the susceptibility regions to psoriasis in Spanish population. Analysis of the chromosomal regions 6p, 17q, 4q and 1cen-q21. PATIENTS AND METHOD: Analysis of 27 Spanish families with psoriasis. Parametric and non-parametric linkage analysis with 22 polymorphic microsatellite markers in the candidate regions. RESULTS: Evidence of linkage (p < 0,05) using non-parametric methods in chromosome 6p. Absence of linkage in 17q, 4q and 1cen-q21 regions. CONCLUSION: We present the evidence of a major gene in 6p21.3 involved in psoriasis in Spanish population.
|Translated title of the contribution||Analysis of the susceptibility regions to psoriasis in Spanish population: Evidence of a major gene involved in psoriasis in 6p21|
|Number of pages||3|
|State||Published - Jun 16 2001|
- Candidate genes
- Genetic linkage
ASJC Scopus subject areas