Analysis of the role of vaccinia virus H7 in virion membrane biogenesis with an H7-deletion mutant

Xiangzhi Meng, Xiang Wu, Bo Yan, Junpeng Deng, Yan Xiang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Essential vaccinia virus genes are often studied with conditional-lethal inducible mutants. Here, we constructed a deletion mutant lacking the essential H7R gene (the δH7 mutant) with an H7-expressing cell line. Compared to an inducible H7 mutant, the δH7 mutant showed a defect at an earlier step of virion membrane biogenesis, before the development of short crescent-shaped precursors of the viral envelope. Our studies refine the role of H7 in virion membrane biogenesis and highlight the values of analyzing deletion mutants.

Original languageEnglish (US)
Pages (from-to)8247-8253
Number of pages7
JournalJournal of virology
Volume87
Issue number14
DOIs
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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