Analysis of SLC19A2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in Pima Indians

Farook Thameem, Johanna K. Wolford, Clifton Bogardus, Michal Prochazka

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Mutations in the SLC19A2 gene cause thiamine-responsive megaloblastic anemia (TRMA) frequently combined with diabetes mellitus and deafness. Type 2 diabetes mellitus is heritable and a region on 1q21-q23 encompassing SLC19A2 was linked with the disease in Pima Indians and Caucasians. We therefore investigated this candidate gene in selected diabetic and nondiabetic Pimas and found no variants. We conclude that mutations in SLC19A2 do not contribute to type 2 diabetes in this population.

Original languageEnglish (US)
Pages (from-to)360-363
Number of pages4
JournalMolecular Genetics and Metabolism
Volume72
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Association analysis
  • Candidate gene
  • Pima Indians
  • SLC19A2
  • Single nucleotide polymorphism
  • TRMA
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology

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