Analysis of SLC19A2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in Pima Indians

Farook Thameem; Johanna K. Wolford; Clifton Bogardus; Michal Prochazka

doi:10.1006/mgme.2001.3154

Analysis of SLC19A2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in Pima Indians

Farook Thameem, Johanna K. Wolford, Clifton Bogardus, Michal Prochazka

Department of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Mutations in the SLC19A2 gene cause thiamine-responsive megaloblastic anemia (TRMA) frequently combined with diabetes mellitus and deafness. Type 2 diabetes mellitus is heritable and a region on 1q21-q23 encompassing SLC19A2 was linked with the disease in Pima Indians and Caucasians. We therefore investigated this candidate gene in selected diabetic and nondiabetic Pimas and found no variants. We conclude that mutations in SLC19A2 do not contribute to type 2 diabetes in this population.

Original language	English (US)
Pages (from-to)	360-363
Number of pages	4
Journal	Molecular Genetics and Metabolism
Volume	72
Issue number	4
DOIs	https://doi.org/10.1006/mgme.2001.3154
State	Published - Jan 1 2001

Keywords

Association analysis
Candidate gene
Pima Indians
SLC19A2
Single nucleotide polymorphism
TRMA
Type 2 diabetes mellitus

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
Genetics
Endocrinology

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10.1006/mgme.2001.3154

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abstract = "Mutations in the SLC19A2 gene cause thiamine-responsive megaloblastic anemia (TRMA) frequently combined with diabetes mellitus and deafness. Type 2 diabetes mellitus is heritable and a region on 1q21-q23 encompassing SLC19A2 was linked with the disease in Pima Indians and Caucasians. We therefore investigated this candidate gene in selected diabetic and nondiabetic Pimas and found no variants. We conclude that mutations in SLC19A2 do not contribute to type 2 diabetes in this population.",

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AU - Prochazka, Michal

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AB - Mutations in the SLC19A2 gene cause thiamine-responsive megaloblastic anemia (TRMA) frequently combined with diabetes mellitus and deafness. Type 2 diabetes mellitus is heritable and a region on 1q21-q23 encompassing SLC19A2 was linked with the disease in Pima Indians and Caucasians. We therefore investigated this candidate gene in selected diabetic and nondiabetic Pimas and found no variants. We conclude that mutations in SLC19A2 do not contribute to type 2 diabetes in this population.

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KW - SLC19A2

KW - Single nucleotide polymorphism

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Analysis of SLC19A2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in Pima Indians

Abstract

Keywords

ASJC Scopus subject areas

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