Analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test

Karl Thomaseth, Amalia Gastaldelli, Alessandra Pavan, Rachele Berria, Leonard Glass, Ralph DeFronzo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A mathematical model based on minimal physiological assumptions for describing simultaneously multiple glucose measurements during modified oral glucose tolerance test is presented. Parameter identification was carried out using a population approach, which allowed precise characterisation of average glucose kinetic parameters in the studied cohort, as well as between-subject variability associated with glucose tolerance state and other covariates. The statistical and computational complexity added with the formulation of non-linear hierarchical population kinetic models is compensated by improved robustness, over the traditional two-stage approach, in selecting the most adequate model structure/order at the individual level and the most significant determinants of glucose kinetics at the population level.

Original languageEnglish (US)
Title of host publication6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006
Pages57-62
Number of pages6
EditionPART 1
StatePublished - Dec 1 2006
Event6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006 - Reims, France
Duration: Aug 20 2006Aug 22 2006

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
NumberPART 1
Volume6
ISSN (Print)1474-6670

Other

Other6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006
CountryFrance
CityReims
Period8/20/068/22/06

Keywords

  • Mathematical models
  • Medical applications
  • Parameter identification
  • Physiological models
  • Reduced-order models
  • Statistical analysis

ASJC Scopus subject areas

  • Control and Systems Engineering

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