Analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test

Karl Thomaseth, Amalia Gastaldelli, Alessandra Pavan, Rachele Berria, Leonard Glass, Ralph A Defronzo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A mathematical model based on minimal physiological assumptions for describing simultaneously multiple glucose measurements during modified oral glucose tolerance test is presented. Parameter identification was carried out using a population approach, which allowed precise characterisation of average glucose kinetic parameters in the studied cohort, as well as between-subject variability associated with glucose tolerance state and other covariates. The statistical and computational complexity added with the formulation of non-linear hierarchical population kinetic models is compensated by improved robustness, over the traditional two-stage approach, in selecting the most adequate model structure/order at the individual level and the most significant determinants of glucose kinetics at the population level.

Original languageEnglish (US)
Title of host publicationIFAC Proceedings Volumes (IFAC-PapersOnline)
Pages57-62
Number of pages6
Volume6
EditionPART 1
StatePublished - 2006
Event6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006 - Reims, France
Duration: Aug 20 2006Aug 22 2006

Other

Other6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006
CountryFrance
CityReims
Period8/20/068/22/06

Fingerprint

Glucose
Kinetics
Model structures
Kinetic parameters
Computational complexity
Identification (control systems)
Mathematical models

Keywords

  • Mathematical models
  • Medical applications
  • Parameter identification
  • Physiological models
  • Reduced-order models
  • Statistical analysis

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Thomaseth, K., Gastaldelli, A., Pavan, A., Berria, R., Glass, L., & Defronzo, R. A. (2006). Analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test. In IFAC Proceedings Volumes (IFAC-PapersOnline) (PART 1 ed., Vol. 6, pp. 57-62)

Analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test. / Thomaseth, Karl; Gastaldelli, Amalia; Pavan, Alessandra; Berria, Rachele; Glass, Leonard; Defronzo, Ralph A.

IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 6 PART 1. ed. 2006. p. 57-62.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Thomaseth, K, Gastaldelli, A, Pavan, A, Berria, R, Glass, L & Defronzo, RA 2006, Analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test. in IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 edn, vol. 6, pp. 57-62, 6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006, Reims, France, 8/20/06.
Thomaseth K, Gastaldelli A, Pavan A, Berria R, Glass L, Defronzo RA. Analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test. In IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 ed. Vol. 6. 2006. p. 57-62
Thomaseth, Karl ; Gastaldelli, Amalia ; Pavan, Alessandra ; Berria, Rachele ; Glass, Leonard ; Defronzo, Ralph A. / Analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test. IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 6 PART 1. ed. 2006. pp. 57-62
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