TY - GEN
T1 - Analysis of double-tracer glucose kinetics in humans during oral glucose tolerance test
AU - Thomaseth, Karl
AU - Gastaldelli, Amalia
AU - Pavan, Alessandra
AU - Berria, Rachele
AU - Glass, Leonard
AU - DeFronzo, Ralph
PY - 2006
Y1 - 2006
N2 - A mathematical model based on minimal physiological assumptions for describing simultaneously multiple glucose measurements during modified oral glucose tolerance test is presented. Parameter identification was carried out using a population approach, which allowed precise characterisation of average glucose kinetic parameters in the studied cohort, as well as between-subject variability associated with glucose tolerance state and other covariates. The statistical and computational complexity added with the formulation of non-linear hierarchical population kinetic models is compensated by improved robustness, over the traditional two-stage approach, in selecting the most adequate model structure/order at the individual level and the most significant determinants of glucose kinetics at the population level.
AB - A mathematical model based on minimal physiological assumptions for describing simultaneously multiple glucose measurements during modified oral glucose tolerance test is presented. Parameter identification was carried out using a population approach, which allowed precise characterisation of average glucose kinetic parameters in the studied cohort, as well as between-subject variability associated with glucose tolerance state and other covariates. The statistical and computational complexity added with the formulation of non-linear hierarchical population kinetic models is compensated by improved robustness, over the traditional two-stage approach, in selecting the most adequate model structure/order at the individual level and the most significant determinants of glucose kinetics at the population level.
KW - Mathematical models
KW - Medical applications
KW - Parameter identification
KW - Physiological models
KW - Reduced-order models
KW - Statistical analysis
UR - http://www.scopus.com/inward/record.url?scp=79961152079&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961152079&partnerID=8YFLogxK
U2 - 10.3182/20060920-3-fr-2912.00015
DO - 10.3182/20060920-3-fr-2912.00015
M3 - Conference contribution
AN - SCOPUS:79961152079
SN - 9783902661180
T3 - IFAC Proceedings Volumes (IFAC-PapersOnline)
SP - 57
EP - 62
BT - 6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006
PB - IFAC Secretariat
ER -